Comparative study of sperm motility in Metformin-using and Insulin-dependent diabetics

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Awais Ali Zaidi Mahtab Ahmed Khan Ali Sharif Lubna Shakir Atif Irshad Arsalan Ali Zaib Ali Shaheryar


Background: Diabetes mellitus (DM) represents one of the greatest threats to modern global health. DM may affect male reproductive function at multiple levels as a result of its effects on spermatogenesis, sperm motility, sperm morphology, and change in sperm structure.

Methods: The present study deals with sperm motility and sperm morphological changes associated with diabetes in the male population. In this study, 50 insulin-dependent and 50 metformin users were selected, with ages of males ranging from 26-54 years and duration of diabetes distributed over 3-15 years. Both insulin-dependent and metformin-using diabetic subjects were evaluated for sperm analysis.

Results: Sperm analysis data showed a significant increase (p ±0.0005) in total sperm count in insulin-dependent diabetic men. However, sperm motility was found to be about 10-15% less in insulin-dependent patients compared to metformin users. Moreover, sperm morphology was improved in 6% of metformin users compared to insulin-dependent diabetics.

Conclusion: Our study concludes that metformin does not significantly affect sperm count. However, it does significantly affect sperm motility, when compared to insulin-dependent diabetic men. This study established an important relationship between diabetes and sperm motility, which reflects the reproductive capabilities of men.


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ZAIDI, Awais Ali et al. Comparative study of sperm motility in Metformin-using and Insulin-dependent diabetics. Biomedical Research and Therapy, [S.l.], v. 4, n. 06, p. 1388-1399, june 2017. ISSN 2198-4093. Available at: <>. Date accessed: 20 aug. 2017. doi:
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