Association between SNP rs9485372 in TAB2 gene and breast cancer risk 
in Vietnamese women

Main Article Content

Nguyen Thi Lan Huong Nguyen Thi Ngoc Thanh Nguyen Thi Hue

Abstract

Background: Breast cancer is a complex and common cancer in women. In the purpose of prevention and treatment of the disease, many studies have been conducted recently all over the world. The genetic factor is known as an important factor has been studied to provide information for early diagnosis. Within several genetic factors involved in the development of breast cancer, TAB2 gene in 6q25.1 is a breast cancer susceptibility locus. The SNP r9485372 in TAB2 gene is associated with breast cancer in East Asian population including Chinese and Korean but not in Indian and Japanese. In this study, we conducted a case-control study to evaluate the association of this SNP with breast cancer risk in the Vietnamese population.

Methods: 109 controls and 111 cases were genotyped by HRM method and logistic regression analysed.

Results: We found that the frequency of SNP alleles is roughly similar to East Asian population: the major allele is G occupied 59.63%, the minor allele is A with 40.37% in the Vietnamese population.  The allelic distribution of SNP rs9485372 was not significantly different between case and control group (ORA vs. G (95% CI) = 0.93 (0.64 - 1.37), P-value = 0.73).

Conclusion: Our finding thus suggested that this SNP is not significantly associated with breast cancer in Vietnamese women. However, the power of this study is quite low at only 4.46% that was partly caused by a small sample size. Hence, a further study needs to be conducted with a larger sample size in the future to confirm the association of this SNP with breast cancer in Vietnamese women.

References

Balmain, A., Gray, J., & Ponder, B. (2003). The genetics and genomics of cancer. Nat Genet, 33, 238-244.
Benson, J. R. (2004). Role of transforming growth factor β in breast carcinogenesis. The lancet oncology, 5(4), 229-239.
Cai, Q., Zhang, B., Sung, H., Low, S.-K., Kweon, S.-S., Lu, W., . . . Choi, J.-Y. (2014). Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32. 1, 5q14. 3 and 15q26. 1. Nature genetics, 46(8), 886-890.
DeSantis, C., Siegel, R., & Jemal, A. (2013). Breast cancer facts and figures 2013-2014. American Cancer Society, 1-38.
DucNB. (2010). Epidemiology and program of control and prevention for cancer: preliminary report of national cancer project period 2008–2010. Viet J Oncol, 21-31.
Easton, D. F., Pooley, K. A., Dunning, A. M., Pharoah, P. D., Thompson, D., Ballinger, D. G., . . . Luben, R. (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447(7148), 1087-1093.
Faulk, C., & Dolinoy, D. C. (2011). Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics, 6(7), 791-797.
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., . . . Bray, F. (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer, 136(5), E359-E386.
Gaudet, M. M., Kuchenbaecker, K. B., Vijai, J., Klein, R. J., Kirchhoff, T., McGuffog, L., . . . Dennis, J. (2013). Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS genetics, 9(3), e1003173.
GLOBOCAN. (2012). GLOBOCAN 2012: Estimated Incidence, Mortality and Prevalence Worldwide in 2012. from http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx
Hue, N. T., Chan, N. D. H., Phong, P. T., Linh, N. T. T., & Giang, N. D. (2012). Extraction of human genomic DNA from dried blood spots and hair roots. International Journal of Bioscience, Biochemistry and Bioinformatics, 2(1), 21.
Levin, P. B. a. B. (2008). World cancer report.
Long, J., Cai, Q., Shu, X.-O., Qu, S., Li, C., Zheng, Y., . . . Cheng, J. (2010). Identification of a functional genetic variant at 16q12. 1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet, 6(6), e1001002.
Long, J., Cai, Q., Sung, H., Shi, J., Zhang, B., Choi, J.-Y., . . . Gao, Y.-T. (2012). Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet, 8(2), e1002532.
Long, J., Zhang, B., Signorello, L. B., Cai, Q., Deming-Halverson, S., Shrubsole, M. J., . . . Easton, D. F. (2013). Evaluating genome-wide association study-identified breast cancer risk variants in African-American women. PloS one, 8(4), e58350.
Martin, A.-M., & Weber, B. L. (2000). Genetic and hormonal risk factors in breast cancer. Journal of the National Cancer Institute, 92(14), 1126-1135.
Nagrani, R., Mhatre, S., Rajaraman, P., Chatterjee, N., Akbari, M. R., Boffetta, P., . . . Dikshit, R. (2017). Association of Genome-Wide Association Study (GWAS) Identified SNPs and Risk of Breast Cancer in an Indian Population. Scientific Reports, 7, 40963. doi: 10.1038/srep40963
Onay, V. Ü., Briollais, L., Knight, J. A., Shi, E., Wang, Y., Wells, S., . . . Ozcelik, H. (2006). SNP-SNP interactions in breast cancer susceptibility. BMC cancer, 6(1), 114.
Pharoah, P. D., Antoniou, A., Bobrow, M., Zimmern, R. L., Easton, D. F., & Ponder, B. A. (2002). Polygenic susceptibility to breast cancer and implications for prevention. Nature genetics, 31(1), 33-36.
Rizzolo, P., Silvestri, V., Falchetti, M., & Ottini, L. (2011). Inherited and acquired alterations in development of breast cancer. Appl Clin Genet, 4, 145.
Shu, X. O., Long, J., Lu, W., Li, C., Chen, W. Y., Delahanty, R., . . . Shi, J. (2012). Novel genetic markers of breast cancer survival identified by a genome-wide association study. Cancer research, 72(5), 1182-1189.
Takaesu, G., Kishida, S., Hiyama, A., Yamaguchi, K., Shibuya, H., Irie, K., . . . Matsumoto, K. TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway. Molecular cell, 5(4), 649-658. doi: 10.1016/S1097-2765(00)80244-0
Turnbull, C., Ahmed, S., Morrison, J., Pernet, D., Renwick, A., Maranian, M., . . . Easton, D. F. (2010). Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet, 42(6), 504-507.
Van Waes, C. (2007). Nuclear factor-κB in development, prevention, and therapy of cancer. Clinical Cancer Research, 13(4), 1076-1082.
Wang, Y., He, Y., Qin, Z., Jiang, Y., Jin, G., Ma, H., . . . Guan, X. (2014). Evaluation of functional genetic variants at 6q25. 1 and risk of breast cancer in a Chinese population. Breast Cancer Research, 16(4), 422.
Wen, W., Shu, X.-o., Guo, X., Cai, Q., Long, J., Bolla, M. K., . . . Gao, Y.-T. (2016). Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. Breast Cancer Research, 18(1), 124.
WHO. (2016). Early detection of cancer. In Cancer. (World Healthy Organizatio).
Zheng, W., Long, J., Gao, Y.-T., Li, C., Zheng, Y., Xiang, Y.-B., . . . Haines, J. L. (2009). Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25. 1. Nature genetics, 41(3), 324-328.
Zheng, W., Zhang, B., Cai, Q., Sung, H., Michailidou, K., Shi, J., . . . Humphreys, M. K. (2013). Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Human molecular genetics, ddt089.

Downloads

Download data is not yet available.

Article Details

How to Cite
HUONG, Nguyen Thi Lan; THANH, Nguyen Thi Ngoc; HUE, Nguyen Thi. Association between SNP rs9485372 in TAB2 gene and breast cancer risk 
in Vietnamese women. Biomedical Research and Therapy, [S.l.], v. 4, n. 07, p. 1451-1462, july 2017. ISSN 2198-4093. Available at: <http://www.bmrat.org/index.php/BMRAT/article/view/198>. Date accessed: 23 oct. 2017. doi: https://doi.org/10.15419/bmrat.v4i07.198.
Section
Research articles