Association between SNP rs9485372 in TAB2 gene and breast cancer risk 
in Vietnamese women

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Nguyen Thi Lan Huong Nguyen Thi Ngoc Thanh Nguyen Thi Hue

Abstract

Background: Breast cancer is a complex and common cancer in women. In the purpose of prevention and treatment of the disease, many studies have been conducted recently all over the world. The genetic factor is known as an important factor has been studied to provide information for early diagnosis. Within several genetic factors involved in the development of breast cancer, TAB2 gene in 6q25.1 is a breast cancer susceptibility locus. The SNP r9485372 in TAB2 gene is associated with breast cancer in East Asian population including Chinese and Korean but not in Indian and Japanese. In this study, we conducted a case-control study to evaluate the association of this SNP with breast cancer risk in the Vietnamese population.


Methods: 109 controls and 111 cases were genotyped by HRM method and logistic regression analysed.


Results: We found that the frequency of SNP alleles is roughly similar to East Asian population: the major allele is G occupied 59.63%, the minor allele is A with 40.37% in the Vietnamese population.  The allelic distribution of SNP rs9485372 was not significantly different between case and control group (ORA vs. G (95% CI) = 0.93 (0.64 - 1.37), P-value = 0.73).


Conclusion: Our finding thus suggested that this SNP is not significantly associated with breast cancer in Vietnamese women. However, the power of this study is quite low at only 4.46% that was partly caused by a small sample size. Hence, a further study needs to be conducted with a larger sample size in the future to confirm the association of this SNP with breast cancer in Vietnamese women.

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How to Cite
HUONG, Nguyen Thi Lan; THANH, Nguyen Thi Ngoc; HUE, Nguyen Thi. Association between SNP rs9485372 in TAB2 gene and breast cancer risk 
in Vietnamese women. Biomedical Research and Therapy, [S.l.], v. 4, n. 07, p. 1451-1462, july 2017. ISSN 2198-4093. Available at: <http://www.bmrat.org/index.php/BMRAT/article/view/198>. Date accessed: 20 aug. 2017. doi: https://doi.org/10.15419/bmrat.v4i07.198.
Section
Research articles