ID:4007 Immune-cell base for cancer therapy

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Van Thanh Ta Thinh Huy Tran Binh Thanh Nguyen Linh Quy Nguyen Hoai Quy Nguyen Khanh Van Tran

Abstract

The development of immune cell-based approaches for treatment of cancer has been actively investigated for many years. One strategy that has been demonstrated as an effective method for cancer treatment is adoptive T cell therapy. The principle of this method is using Cytotoxic T lymphocytes (CTL), a crucial component of the adaptive immune system that aids in the control of intracellular pathogens. Effector CTL have the capacity to promote the apoptotic death of specifically targeted cells, using a combination of granule (perforin/granzyme)-and receptor (Fas/tumor necrosis factor)-mediated mechanisms. CTL recognize specific antigen on target cells using an unique T-cell receptor (TCR) when they are presented by class I major histocompatibility (MHC) molecules. In this study, we demonstrated that T lymphocytes were activated and dramatically expanded by stimulation with anti-CD3/CD28 antibodies and culture in the present of IL-2, IL-15 and IL-21 cytokines. These T cells exhibited a predominantly activated phenotype as manifested by an increase in the percentage of cells expressing CD8 and generation of various cytokines such as IL-2, INFγ and TNFa. These findings indicate that stimulation by anti- CD3/CD28 generated effector CTL in adoptive T-cell therapy for cancer.

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How to Cite
TA, Van Thanh et al. ID:4007 Immune-cell base for cancer therapy. Biomedical Research and Therapy, [S.l.], v. 4, n. S, p. S10, sep. 2017. ISSN 2198-4093. Available at: <http://www.bmrat.org/index.php/BMRAT/article/view/217>. Date accessed: 23 oct. 2017. doi: https://doi.org/10.15419/bmrat.v4iS.217.
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Oral Abstracts