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Porous nanosilica (PNS) has been attracting a growing attention in fabrication of carriers for drug delivery system (DDS). However, unmodified PNS-based nanocarriers exhibit the initial burst release of encapsulated bioactive molecules, which may limit their potential clinical applications. In this report, the surface of PNS was conjugated with gelatin-poly (ethylene glycol) methyl ether (GEL-mPEG) to form a core-shell structure PNS-GEL-mPEG for doxorubicin (DOX) delivery. The conjugated PNS carriers were found to be spherical in shape with diameter range of approximately 55-85 nm as compared with their parentally PNS (55-67 nm). The PNS-GEL-mPEG nanoparticles showed their ability to effectively encapsulate DOX for controlled release. In detail, DOX was efficiently loaded into the PNS-GEL-mPEG to form DOX-loaded nanocarriers (DOX@PNS-GEL-mPEG) with high loading efficiency (79.7%). The release of DOX from DOX@PNS-GEL-mPEG was prolonged and controlled up to 96 h in phosphate buffered saline (PBS, pH 7.4, 37 oC) without any initial burst release. These results demonstrated that this PNS-GEL-mPEG can be a potential candidate for controlled DDS with high loading capacity in cancer therapy

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Nguyen, H. (2017). ID3009 Gelatin-Poly (Ethylene Glycol) Methyl Ether-Functionalized Porous Nanosilica for Controlled Doxorubicin Delivery. Biomedical Research and Therapy, 4(S), S22.

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