ID:2040 Antileukemic and antiplatelet activities of indirubin-3'-oxime, an active ingredient semi-synthesized from indirubin-rich powder of medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae)

Main Article Content

Cuong Nguyen Manh

Abstract

Indirubin-3’-oxime (IOX) is an active ingredient semi-synthesized from indirubin-rich powder produced from medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae). IOX exhibits antileukemic and antiplatelet activities. IOX inhibited the growth of human promyelocytic leukemia HL-60 cells with a GI50 value of 36.6 µM. Oral administration (20 mg kg-1day-1) of IOX for 3 days significantly prolonged occlusion time in a rat carotid artery injury model, and ADP- and collagen-induced platelet aggregation, comparable with aspirin. IOX markedly reduced collagen-induced phosphorylation of extracellular signal-regulated kinase ERK1/2 and p47, resulting in the blockade of cyclooxygenase (COX)-mediated AA metabolite production in AA-treated platelets. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic and antiplatelet drug

References

1. Nguyễn Mạnh Cường, Hồ Việt Đức, Nguyễn Văn Tài, Phạm Ngọc Khanh, Trần Thu Hường, Vũ Thị Hà, Nguyễn Thị Bích Thảo, Cải tiến phương pháp tổng hợp indirubin-3’-oxim từ bột chàm giàu indirubin và ứng dụng tạo chế phẩm hỗ trợ điều trị bệnh ung thư. Tạp chí Hóa học, 2012, T.50(5A), 320-322.
2. Nguyen Manh Cuong, Bui Huu Tai, Dang Hoang Hoan, Tran Thu Huong, Young Ho Kim, Jae-Hee Hyun, Hee-Kyoung Kang, Inhibitory Effects of Indirubin Derivatives on the Growth of HL-60 Leukemia Cells, Natural Product Communications, 2010, 5(1), 103-106.
3. Jung-Jin Lee, Joo-Hui Han, Sang-Hyuk Jung, Sang-Gil Lee, In-Su Kim, Nguyen Manh Cuong, Tran Thu Huong, Pham Ngoc Khanh, Young Ho Kim, Yeo-Pyo Yun, Jin Yeul Ma, Chang-Seon Myung, Antiplatelet action of indirubin-3’-monoxime through suppression of glycoprotein VI-mediated signal transduction: A possible role for ERK signaling in platelets, Vascular Pharmacology 11/2014; 63, 182-192. DOI: 10.1016/j.vph.2014.10.005, ISSN: 1537-1891, impact factor 4.62 (2014).
4. Nguyễn Mạnh Cường, Phạm Ngọc Khanh, Trần Thu Hường, Nguyễn Ngọc Hiếu, Hồ Việt Đức, Vũ Thị Hà, Nguyễn Văn Tài, Nguyễn Thị Hồng Vinh, Nghiên cứu độc tính cấp và bán trường diễn của indirubin-3’-oxim và viên nang VINDOXIM hỗ trợ điều trị bệnh ung thư, Tạp chí Khoa học và Công nghệ, 2013, 51(3), 343 -352.

Downloads

Download data is not yet available.

Article Details

How to Cite
NGUYEN MANH, Cuong. ID:2040 Antileukemic and antiplatelet activities of indirubin-3'-oxime, an active ingredient semi-synthesized from indirubin-rich powder of medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae). Biomedical Research and Therapy, [S.l.], v. 4, n. S, p. S71, sep. 2017. ISSN 2198-4093. Available at: <http://www.bmrat.org/index.php/BMRAT/article/view/278>. Date accessed: 20 oct. 2017. doi: https://doi.org/10.15419/bmrat.v4iS.278.
Section
Oral Abstracts