ID: 1031 Synthesis of Polymeric Nanoparticles of α-mangostin and its Cytotoxicity to Human Cancer Cell Lines
α-Mangostin (AMG) extracted from Garcinia mangostana L., has potent anti-cancer properties, however its clinical application is limited due to poor aqueous-solubility. Here, we successfully synthesised and characterised water-soluble ß-cyclodextrin-coated AMG 30-50 nm-size nanoparticles (NMG). Similar cytotoxic activities against LU-1 (human lung adenocarcinoma) and HL-60 (human promyelocytic leukemia) cancer cells of water-soluble NMG and organic-solvent soluble AMG were found with IC50 of 8.86 and 9.86 µg/mL, respectively. The data demonstrates that the nanoparticles improve bioavailability while maintain anti-cancer activity of AMG.
2. P.T.M. Nguyen, M.L. Falsetta, G. Hwang, M. Gonzalez, H. Koo. Plos One . 2014, 9, e1113122014.
3. A.F. Aisha, Z. Ismail, K.M. Abu-Salah, A.M. Majid. J. Pharm. Sci. 2012, 101, 815
4. P. Pan-In, A. Wongsomboon, C. Kokpol, N. Chaichanawongsaroj, S. Wanichwecharungruang. J. Pharmacol. Sci. 2015, 129, 226.
5. S. Qiu, R. Granet, J.P. Mbakidi, F. Brégier, C. Pouget, L. Micallef, T. Sothea-Ouk, D.Y. Leger, B. Liagre, V. Chaleix, V. S ol. Bioorg. Med. Chem. Lett. 2016, 26, 2503
Volume & Issue : Vol 4 No S (2017): Abstract Proceeding: International conference INNOVATIONS IN CANCER RESEARCH AND REGENERATIVE MEDICINE 2017
Page No.: S 106
Published on: 2017-08-31
Copyrights & License
This work is licensed under a Creative Commons Attribution 4.0 International License.
- HTML viewed - 1519 times
- Download PDF downloaded - 714 times