TY - JOUR AU - Awais Zaidi AU - Mahtab Khan AU - Ali Sharif AU - Lubna Shakir AU - Atif Irshad AU - Arsalan Ali AU - Zaib Shaheryar PY - 2017/06/25 Y2 - 2024/03/28 TI - Comparative study of sperm motility in Metformin-using and Insulin-dependent diabetics JF - Biomedical Research and Therapy JA - BMRAT VL - 4 IS - 06 SE - Original Research DO - 10.15419/bmrat.v4i06.180 UR - http://bmrat.org/index.php/BMRAT/article/view/180 AB - Background: Diabetes mellitus (DM) represents one of the greatest threats to modern global health. DM may affect male reproductive function at multiple levels as a result of its effects on spermatogenesis, sperm motility, sperm morphology, and change in sperm structure.Methods: The present study deals with sperm motility and sperm morphological changes associated with diabetes in the male population. In this study, 50 insulin-dependent and 50 metformin users were selected, with ages of males ranging from 26-54 years and duration of diabetes distributed over 3-15 years. Both insulin-dependent and metformin-using diabetic subjects were evaluated for sperm analysis.Results: Sperm analysis data showed a significant increase (p ±0.0005) in total sperm count in insulin-dependent diabetic men. However, sperm motility was found to be about 10-15% less in insulin-dependent patients compared to metformin users. Moreover, sperm morphology was improved in 6% of metformin users compared to insulin-dependent diabetics.Conclusion: Our study concludes that metformin does not significantly affect sperm count. However, it does significantly affect sperm motility, when compared to insulin-dependent diabetic men. This study established an important relationship between diabetes and sperm motility, which reflects the reproductive capabilities of men. ER -