TY - JOUR AU - Hala Mansoor AU - Muhammad Adnan Masood AU - Kashif Siddique AU - Farhana Badar AU - Muhammed Aasim Yusuf PY - 2019/11/29 Y2 - 2024/03/29 TI - Clinical features and survival of patients with hepatocellular carcinoma at a cancer treatment facility JF - Biomedical Research and Therapy JA - BMRAT VL - 6 IS - 11 SE - Report DO - 10.15419/bmrat.v6i11.577 UR - http://bmrat.org/index.php/BMRAT/article/view/577 AB - Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. This study aimed to determine the survival of patients with HCC at our treatment facility.Methods: We retrospectively studied 278 patients with HCC who were seen between 2007 and 2013. Of these patients, 84.4% had evidence of prior infection with hepatitis C, while 7.8% had markers of hepatitis B infection.Results: Median survival was 24.6 months for transarterial chemoembolization (TACE), 61 months for ablative therapies, and 31.5 months for those undergoing surgical resection. Increasing tumor size, multifocality, advanced Barcelona clinic liver cancer (BCLC) stage, and poor liver function (Child-Pugh class B-C) were significantly associated with worse prognosis; pvalues were 0.002, 0.009, <0.001, and <0.001, respectively.Conclusion: Most patients in our series presented with advanced liver disease, with multifocal tumors and were candidates for palliative treatment only. Public education to minimize hepatitis B and C transmission, screening programs to detect disease at an earlier stage, and the development of specialist liver units and liver transplant programs can bring a change in HCC survival in developing countries.  ER -