TY - JOUR AU - Nguyen Hung AU - Nguyen Huong AU - Nguyen Thanh AU - Tran Minh AU - Dao Luan PY - 2022/06/30 Y2 - 2024/03/29 TI - Extranodal primary CD20-negative diffuse large B-cell lymphoma with cytoplasmic p16 expression JF - Biomedical Research and Therapy JA - BMRAT VL - 9 IS - 6 SE - Case report DO - 10.15419/bmrat.v9i6.743 UR - http://bmrat.org/index.php/BMRAT/article/view/743 AB - Extranodal primary CD20-negative diffuse large B-cell lymphoma (DLBCL) is a rare tumor. It often presents a diagnostic challenge for pathologists as the morphological features of neoplastic cells are similar to those of undifferentiated carcinoma or sarcoma cells. While several B-cell markers are commonly tested, expanding the panel of B-cell markers is necessary to ascertain definitive DLBCL diagnoses and would assist in decisions regarding treatment and prognoses. Several additional markers have been proposed, including several mutated genes commonly expressed in cancer cells, such as c-Myc, Bcl6/c-Myc, Bcl6, Bcl2 (double/triple expressors), as well as cytoplasmic p16. ER -