Biomedical Research and Therapy http://www.bmrat.org/index.php/BMRAT <div class="slider-container"> <h2>Featured Articles</h2> <div id="myCarousel" class="carousel slide" style="height: 300px; padding: 50px;" data-ride="carousel"><!-- Indicators --> <!-- FEATURED ARTICLES CONTENT HERE --> <div class="carousel-inner"> <div class="item active"><a href="http://www.bmrat.org/index.php/BMRAT/article/view/287">Concise review: Extracellular vesicles from mesenchymal stem cells as cellular therapy </a> <div>Recently, new methods have been developed to isolate and enrich EVs with high performance and low-toxicity. Thus, EVs have emerged as the new generation of stem cell therapy. This concise review aims to highlight some recent achievements of EVs in preclinical and clinical applications.</div> </div> <div class="item"><a href="http://www.bmrat.org/index.php/BMRAT/article/view/198">Association between SNP rs9485372 in TAB2 gene and breast cancer risk 
in Vietnamese women </a> <div>Our finding thus suggested that this SNP is not significantly associated with breast cancer in Vietnamese women. However, the power of this study is quite low at only 4.46% that was partly caused by a small sample size. Hence, a further study needs to be conducted with a larger sample size in the future to confirm the association of this SNP with breast cancer in Vietnamese women.</div> </div> <div class="item"><a href="http://www.bmrat.org/index.php/BMRAT/article/view/178">Up-to-date clinical approaches of biomarkers’ use in heart failure</a> <div>Heart failure (HF) is considered a leading cause of death in patients with established cardiovascular (CV) and metabolic diseases. Although current treatment strategy has improved survival rate and clinical outcomes of HF, the HF prevalence exhibits growth especially in older patients’ population and survivors after coronary atherothrombotic events. Current clinical guidelines regarding treatment and prevention of HF claim the role of biological markers as pretty easy and powerful tool for diagnosis, risk stratification, and prognostication of HF.</div> </div> <div class="item"><a href="http://www.bmrat.org/index.php/BMRAT/article/view/179">Comparative treatment efficiency of adipose and bone marrow derived allogenic mesenchymal stem cell transplantation in mouse models of liver fibrosis </a> <div>After 21 days of transplantation, the results showed that the stem cell treated groups ameliorated better than the placebo group. MSC treated groups showed reduced AST and ALT levels, down-regulated expression of extracellular matrix (ECM) genes, and improved liver histopathology. Both sources of MSCs (bone marrow and adipose tissue) were effective in the mouse model of liver fibrosis.</div> </div> <div class="item"><a href="http://www.bmrat.org/index.php/BMRAT/article/view/182">Determinants of placenta previa: a case-control study </a> <div>The OR of placenta previa was 4.08 (95% CI= 1.44, 11.58) by maternal age, 4.08 (95% CI =1.44, 11.58) by preterm labor, and 6.64 (95% CI =1.09, 40.45) by prior operations of the uterine cavity, compared to normal deliveries and after adjusting for other variables. Multiparity, prior spontaneous abortions, and prior cesarean sections were not statistically significant risk factors for placenta previa, when adjusted for other variables.</div> </div> <div class="item"><a href="http://www.bmrat.org/index.php/BMRAT/article/view/203">Evaluation of Quetiapine Fumarate and its Solid Lipid Nanoparticles as antipsychotic drug in rat model of schizophrenia </a> <div>QFSLN treatment showed enhanced effect over QF in a dose-dependent manner with minimal side effects in schizophrenic rats. In addition, immunohistochemical examinations of brain tissues confirmed the biochemical data.</div> </div> </div> <!-- Left and right controls --> <p><a class="left carousel-control" href="#myCarousel" data-slide="prev"><span class="glyphicon glyphicon-chevron-left"><span style="display: none;">left-arrow</span></span> <span class="sr-only">Previous</span> </a> <a class="right carousel-control" href="#myCarousel" data-slide="next"><span class="glyphicon glyphicon-chevron-right"><span style="display: none;">left-arrow</span></span><span class="sr-only">Next</span> </a></p> </div> </div> BioMedPress (BMP) en-US Biomedical Research and Therapy 2198-4093 <p>Copyright The Author(s) 2017. This article is published with open access by <a href="http://www.biomedpress.org/" target="_blank">BioMedPress</a>. This article is distributed under the terms of the&nbsp;<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">Creative Commons Attribution License (CC-BY 4.0)</a> which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.&nbsp;</p> The most useful medicinal herbs to treat diabetes http://www.bmrat.org/index.php/BMRAT/article/view/463 <p>Diabetes mellitus is a syndrome that is characterized by hyperglycemia, change in the metabolism of lipids, carbohydrates, and proteins, and in the long term, with eye, kidney, cardiovascular, and neurological complications. Plenty of plants from different regions of the world have been investigated for anti-diabetic effects. This review article was designed to report some of the most important medicinal plants with hypoglycemic properties according to reliable clinical and laboratory evidence, and also touched on the medicinal plants that are prescribed in Iranian traditional medicine, for the treatment of diabetes. The information in this review was obtained from the eligible articles retrieved using the search terms diabetes mellitus, medicinal plants, type 1 diabetes and medicinal plants, type 2 diabetes and medicinal plants, and the effect of extract and essential oil of medicinal plants affecting diabetized tissues in the human body indexed in databases such as Iran medex, Irandoc, ISI, PubMed, Scopus, SID, Magiran, Google Scholar, etc. Based on the results drawn in this review the plants, <em>Urtica, Trigonella foenum-graecum, Allium sativum, Carthamus tinctorius, Ferula assa-foetida, Bauhinia, Gymnema sylvestre, Swertia, Combretum, Sarcopoterium, Liriope, Caesalpinia bonduc, Coccinia grandis, Syzygium cumini, Mangifera indica, Momordica charantia, Ocimum tenuiflorum, Pterocarpus, Tinospora cordifoli, Salvia officinalis, Panax, Cinnamomum verum, Abelmoschus moschatus, Vachellia nilotica, Achyranthes, Fabaceae, Mentha, Asphodelaceae, Andrographis paniculata L, Artemisia herba-alba, Artemisia dracunculus, Azadirachta indica, Caesalpinioideae, Pachira aquatic, Gongronema latifolium, Nigella Sativa, Tinospora cordifolia (guduchi), Chrysanthemum morifolium, Zingiber zerumbet, Symphytum, Cactaceae, Symplocos, Perilla frutescens, Terminalia chebula</em> and <em>Aloe vera</em> are effective to controland treat diabetes.</p> Behzad Moradi Saber Abbaszadeh Somayeh Shahsavari Mohsen Alizadeh Fatemeh Beyranvand ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2018-08-21 2018-08-21 5 8 2538 2551 10.15419/bmrat.v5i8.463 title description none g Inflammation in Alzheimer’s disease: A friend or foe? http://www.bmrat.org/index.php/BMRAT/article/view/464 <p><strong>Background</strong>: There is a dearth of precise information for molecular and cellular mechanisms responsible for the development of Alzheimer’s disease (AD). However, convincing data from clinical research and basic molecular biology have shown that inflammation of the brain is an integral part of AD. In this review, the role of inflammation in AD will be highlighted.</p> <p><strong>Methods</strong>: Articles from credible scientific databases, such as ScienceDirect, Scopus, PubMed, Google Scholar and Mendeley, were searched and retrieved using keywords ‘inflammation’, ‘Alzheimer’s disease’, ‘tau’, and ‘beta amyloid’.</p> <p><strong>Results</strong>: At present, there is no local inflammatory-inciting factor that is closely associated with AD, although it has been proposed that inflammation could be induced by pathologic hallmarks of AD, such as beta amyloid (Aβ) peptide plagues and neurofibrillary tangles (NFTs), or fragments of degenerated neurons. However, it is still unclear whether inflammation leads to the development of AD or if the pathological hallmarks of AD induce inflammation.</p> <p><strong>Conclusion</strong>: Inflammation is, indeed, an integral part of AD. Further studies on inflammatory-targeted therapies for AD are highly recommended.</p> Samaila Musa Chiroma Mohamad Taufik Hidayat Baharuldin Che Norma Mat Taib Zulkhairi Amom Saravanan Jagadeesan Mohamad Aris Mohd Moklas ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2018-08-21 2018-08-21 5 8 2552 2564 10.15419/bmrat.v5i8.464 title description none g