journal description

Biomedical Research and Therapy - The Vietnamese Journal of Biomedicine fully open access journal of original research across a broad spectrum of medical scientific disciplines and sub-specialties. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.

Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. 

The journal is published monthly, 12 issues per year.


COVID-19 collection

A collection of new and previously published articles on coronavirus research and treatment. Please click here.


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Research articles

Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma

by Abosharaf H., Salah M., Diab T., Tsubaki M., Mohamed T.

Summary: Plant-mediated synthesis of silver nanoparticles (AgNPs) is accounted as an ecofriendly process. The present study was conducted to estimate the potency of biogenic AgNPs against Ehrlich ascites carcinoma (EAC) cells in vitro and EAC-bearing mice in vivo.


Probiotics: Helpful for the prevention of COVID-19?

by Zafar N., Aslam M., Ali A., Khatoon A., Nazir A., Tanveer Q., Bilal M., Kanwar R., Qadeer A., Sikandar M., Zafar A.

Summary: Up to now, no vaccine has been developed for COVID-19 treatment. Although many scientists are working for the rapid development of a vaccine to control this pandemic, nonetheless, it will take time. If the vaccine will be developed soon, it will not be available to the entire world instantly since the mass production of the vaccine will take time. In this scenario, we will have to take alternative measures to control the COVID-19 pandemic. These alternative approaches include the stimulation of the immune system to fight against viral infections. Among the different approaches to strengthen the immune system, the use of probiotics is the best one. Probiotics can help the body to fight against COVID-19 directly and indirectly. In this review, we comprehensively discuss the use of probiotics for the prevention and control of COVID-19.


Clinical decision-making approaches by health caregivers of patients with COVID-19

by Taghadosi M., Ajorpaz N., Aghajani M.

Summary: The Coronavirus disease of 2019 COVID-19) is the current health crisis in the world- a new, complex phenomenon that has affected and hospitalized many people around the world. Health care providers deal with COVID-19 patients daily and care for the patients while there is no definitive cure for it. Clinical decision-making is an important task of health professionals that plays an essential role in preserving the patient's life and providing quality care. Therefore, understanding clinical decision-making approaches by healthcare providers, such as nurses and physicians, especially in crises such as COVID-19, is essential.


Kidney damage by COVID-19 and rationale for extracorporeal therapies

by Mehreen U., Ali A., Khatoon A., Zafar N., Tanveer Q., Basit I.

Summary: Without doubt, there is some involvement of the kidney in novel coronavirus disease (COVID-19), which is responsible for multiple organ dysfunctions resulting in severe complications in the human body. This newly discovered COVID-19 has incited panic globally. However, the role of kidney involvement in the novel COVID-19 disease is still unclear. In this commentary, we discuss the various pathways involved in kidney damage by COVID-19, and the rationale for extracorporeal support with various blood purification strategies in critically ill people with COVID 19.

Case report

Novel fenofibrate adverse effect in resistant hypertension: A case report

by Barrouq D., Irshaidat T.

Summary: Silent uncontrolled hypertension can cause major organ damage.

Case report

Primary primitive neuroectodermal tumor of the orbit in an adult: Case report and literature review

by Geramizadeh B., Azizi M., Daryakar A., Rafiee F.

Summary: Primitive neuroectodermal tumors (PNETs) are malignant soft tissue tumors of neuroepithelial origin with an aggressive nature and associated with early disseminated metastasis, resulting in poor prognosis. It occurs more frequently in men of age < 35 years, and in several parts of the body, such as pulmonary tract, nasal cavity, paranasal sinuses, and/or neck. Orbital location is infrequent and has been reported in less than 20 cases in the English literature so far.

Case report

Epiploic appendagitis diagnosis linked to intestinal symptoms: Case reports

by Ronny R.

Summary: Epiploic appendices are small pouches filled with projection-like fat structure adjacent to the antimesenteric side of the colon wall; they range in size from 0.5 to 5 cm and provide vascularization from small arterioles. Epiploic appendagitis is a benign condition of the epiploic appendices which leads to ischemia of the structure. Ischemia, therefore, causes localized sharp abdominal pain. Though uncommon, its symptoms can be diagnosed as acute lower abdominal pain since the symptoms could mimic diverticulitis and appendicitis. Thus, to diagnose epiploic appendagitis in this case, a CT scan was conducted to detect a fat-dense lesion of ovoid-like structure close to the colon. Given the good response to conservative management, establishing a correct diagnosis could help to minimize inappropriate invasive management.

Research articles

Toxicity effects of Cubic Cu2O nanoparticles on defecation rate and length in C. Elegans

by Zizzo J.

Summary: The increased presence of radiation and toxins in the atmosphere has given rise to fuel cells and nanoparticle technology with the ability to catalyze reactions at favorable energy levels. The purpose of this experiment was to determine the lasting effects of a synthesized catalyst on a model organism, Caenorhabditis (C.) elegans.

Research articles

Characterization of synovium-derived mesenchymal stem cells from joints with osteochondritis dissecans

by Rao S., Shetty S., Nitilapura N., Shetty V., Parashiva G., K., Basavarajappa M. K.

Summary: Osteochondritis dissecans (OCD) is a pathologic condition that occurs in children as well as adults. OCD is often managed based on the extent of ischemia and the stage of the disease. Synovial tissue collected during an arthroscopic procedure might serve as an ideal source for autologous mesenchymal stem cells (MSCs) with a potential for regenerative medicine of cartilage. Therefore, the present in vitro study aimed to evaluate the potency characteristics of synovium-derived MSCs (SMSCs) from joints with OCD for prospective autologous therapy.

Short Communication

Relapses of desquamative glossitis in patients with gastroesophageal reflux disease

by Emelyanova N.

Summary: This article addresses the issues of pathological manifestations on the tongue of patients with gastroesophageal reflux disease (GERD), as well as the duration of the remission period after treatment. It was revealed that the patients with GERD who received treatment for desquamative glossitis noted a significant decrease in the intensity of subjective and objective manifestations immediately after treatment. However, in cases where no repeated courses of treatment were undertaken, an unstable remission was observed in the oral cavity and new desquamation foci appeared on the tongue. As an example, the article describes the clinical case of a patient with GERD manifestations in the oral cavity who received treatment for desquamative glossitis in 2011.


Antibacterial cellulose-based aerogels for wound healing application: A review

by Yahya E., Alzalouk M., Alfallous K., Abogmaza A.

Summary: Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.


Microcirculatory effects of systemic metabolic correction with reactive oxygen species: An experimental study

by Martusevich A., Karuzin K., Dilenyan L., Peretyagin S.

Summary: The purpose of this study is to estimate microcirculation changes under systemic (intraperitoneal) administration of ozonized saline.

Case report

Convalescent plasma successfully treats a severe COVID-19 patient with multi-organ failure

by Bajelan B., Salehifar P., Karami A., Salimi M., Janbakhsh A., Maleki Z., Farhadi K., Karimi B., Tahmasebi M., Ghasemi A., Gholami A., Sayad B., Payandeh M.

Summary: Due to the high mortality rate of coronavirus disease 2019 (COVID-19) and the lack of specific treatment for the disease, it is essential to find new therapies. The present case report aimed to assess the efficiency of convalescent plasma in patients with severe acute respiratory syndrome coronavirus 2. We reported a severe case of COVID-19 with multi-organ failure, who had reduced oxygen saturation after several courses of antiviral therapy. Moreover, computed tomography (CT) scan results showed patchy lesions in the base of lungs. Therapeutic measures, including endotracheal intubation and plasmapheresis with convalescent plasma, were performed for the patient; subsequently, good responses to the treatments were observed. Our findings demonstrate that convalescent plasma improves pulmonary lesions and the patient's clinical status.


Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry

by Allaq A., Sidik N., Abdul-Aziz A., Ahmed I.

Summary: Cumin (Cuminum cyminum L.) is an annual plant that is not only one of the most popular seed species but also one of the oldest and most cultivated aromatic and herbaceous natural products with numerous medicinal, nutraceutical, and pharmaceutical properties. It is widely used in the beverage, food, liquor, medicine, perfume, and toiletry industries. The objective of this work was to provide a precise and up-to-date review of the ethnopharmacology, phytochemistry, and biological activities of cumin.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

Why publish with Biomedical Research and Therapy




Aims & Scope of Biomedical Research and Therapy updated


Biomedical Research and Therapy (ISSN 2198-4093) was published by Springer in Global Science Journals from 2014-2015, and BioMedPress from 2016 to now. As a result of a revolution, and to improve the journal quality, the publisher decided to revise the aims and scope of Biomedical Research and Therapy.

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Copyright 2014-2018 BioMedPress. This work is licensed under a Creative Commons Attribution 4.0 License. A partner of HINARI, AGORA, OARE, Crossref