journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

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Research articles

Selecting euploid embryo for transfer by preimplantation genetic testing for aneuploidy improved clinical outcomes in patients with advanced maternal age

by Phuong L., Thuc V., Quan P., Anh L., Vinh D., Huyen N.

Summary: This study aimed to investigate whether selecting euploid embryos by preimplantation genetic testing for aneuploidy (PGT-A) can improve the clinical outcomes in patients with advanced maternal age. Hence, it provides evidence about the role of PGT-A in the treatment for patients with advanced maternal age in Vietnam.

Research articles

Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles

by Mailafiya M., M., Abubakar K., Danmaigoro A., Chiroma S., M., Rahim E., B., A., Moklas M., A., M., Zakaria Z. A. B.

Summary: Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability as a result of insolubility. This has necessitated the search for natural inorganic materials for curcumin delivery. Cockleshells are external hard materials of marine animals often treated as unwanted wastes, which are excellent sources of calcium carbonate. This study aimed to synthesize cockle shell-derived calcium carbonate (aragonite) nanoparticles (CSCaCO3NP) for delivery of curcumin and to evaluate its kinetic release in vitro.


Can environmental factors increase the risk of multiple sclerosis? A narrative review

by Naghshineh H., Hojjati S., M., M., Khatir A., A., Saadat P., Ahangar A. A.

Summary: Multiple sclerosis (MS) is one of the most common neurological disorders, which causes nontrauma in young adults in many countries. An important symptom of a disease is the presence of plaque in the brain or the spinal cord, which includes a demyelination region along with relative preservation of axons that may vary in acute and chronic stages. This review was conducted using related keywords through searching in scientific databases. Assessing the related papers showed that in general, MS is recognized as an autoimmune disease with genetic background caused by uncertain environmental factors. Epidemiological effects based on race, sex, geographical location are strongly linked to the frequency, types and severity of the disease. Vitamin D, infection, smoking and diet have been reported to be potential factors associated with MS. Due to the importance of these factors in MS disease, the control of them is potentially useful to prevent the disease and the rapid progression and exacerbation of its symptoms.

Research articles

Efficacy of fixed dose of triple combination of perindopril-indapamide-amlodipine in obese patients with moderate-to-severe arterial hypertension: an open-label 6-month study

by Koval S., Snihurska I., Starchenko T., Penkova M., Mysnychenko O., Yushko K., Lytvynova O., Vysotska O., Berezin A.

Summary: Arterial hypertension (AH) remains the most common cardiovascular (CV) risk factor worldwide.


Clinical features and survival of patients with hepatocellular carcinoma at a cancer treatment facility

by Mansoor H., Masood M., A., Siddique K., Badar F., Yusuf M. A.

Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. This study aimed to determine the survival of patients with HCC at our treatment facility.


Features of sensitization and quality of life of patients with allergic rhinitis: A study in North Viet Nam

by Kryukov A., I., Bondareva G., P., Nguyen T. P. T.

Summary: Allergic rhinitis (AR) is a critical disease related to otorhinolaryngology, allergology, and pediatrics worldwide due to its high prevalence and treatment costs. This article considers its prevalence based on regional characteristics of sensitization and the quality of patients with allergic rhinitis in North Vietnam.


Chemicals used for the induction of Alzheimer’s disease-like cognitive dysfunctions in rodents

by Mahdi O., Baharuldin M., T., H., Nor N., H., M., Chiroma S., M., Jagadeesan S., Moklas M. A. M.

Summary: Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia, characterised by multiple cognitive impairments and personality changes. Different methods including chemicals have been used to induce AD-like symptoms in rodent in order to screen many therapeutic drugs for a variety of cognitive dysfunctions. Articles from reliable databases such as Google Scholar, Science Direct, PubMed, Scopus, and Ovid were searched and retrieved with the following descriptors: 'Alzheimer's Disease', Cognitive impairments', Neurotoxins that induce AD', Alzheimerogenic chemicals', excitotoxins', Amyloid beta', neurofibrillary tangles. A number of chemicals have been studied to develop an animal model of AD on the basis of their mechanism of action for cognitive dysfunctions. Some of such chemicals are Heavy metals, Scopolamine, Ethanol, Colchicine, Streptozotocin, Lipopolysaccharide, and Okadaic acid among others, with a view to understanding the pathogenesis of this devastating disease. The purpose of this review is to put forward some AD pathophysiology including AD causative theories and also highlight some Alzheimerogenic chemicals for the purpose of enriching our existing knowledge. It is worth mentioning that not all the biochemical, histopathological, cognitive and behavioural abnormalities can be recapitulated. Nonetheless, experimental models of AD produced by chemicals offer insights to unravelling the pathogenesis of the disease.

Research articles

Evaluation of the safe consumption of aqueous extract of flour from Stichopus variegates

by Ridhowati S., Chasanah E., Syah D., Zakaria F.

Summary: Sea cucumbers of phylum Echinodermata and class Holothuroidea are found on the seafloor worldwide and are widely used in Asian folk medicine. Objective: In this article, our team provide information of the safety consumption as a reference material for the development of functional foods derived from sea cucumber flour.

Research articles

Clinicopathological correlation of invasive squamous cell carcinoma of uterine cervix: A cross-sectional study

by Raju K., CV R., SR S.

Summary: Cervical cancer is a common cancer in females. Clinicopathological features vary and are heterogeneous in different studies. This study was taken up to know the clinicopathological correlation in squamous cell carcinoma (SCC) of the cervix in our population.

Research articles

Ethanol extract of Ginger Zingiber officinale Roscoe by Soxhlet method induces apoptosis in human hepatocellular carcinoma cell line

by Nguyen S., Vo P., Nguyen T., Do N., Le B., Dinh D., Truong K., Pham P.

Summary: Ginger has had a long history of use in healthcare in Asian countries, including Vietnam. Internationally, there have been a few studies done to assess the anticancer activity and potency of ginger. In this study, we investigated the activity (cytotoxicity) of various ginger root extracts that were produced by different preparation methods on human hepatocellular carcinoma cell line (HepG2 cell line).

Research articles

The effects of the Panax Vietnamensis ethanol fraction on proliferation and differentiation of mouse neural stem cells

by Do H., Q., Truong N., H., Lam T., T., Nguyen L., T., Le D., M., Dinh N., H.,-T., Tran L., C., Le P., T.,-B., Phan N., K., Pham P. V.

Summary: Panax vietnamensis Ha et Grushv. (Ngoc Linh ginseng) – a new species recently discovered in Vietnam – has received much interest due to its rich content of saponins, including those unknown. This study assessed the effects of the Ngoc Linh ginseng extract fractions on proliferation and differentiation of cultured mouse neural stem cells.

Research articles

Comparable effect of adipose-derived stromal vascular fraction and mesenchymal stem cells for wound healing: An in vivo study

by Karina K., Rosadi I., Sobariah S., Afini I., Widyastuti T., Rosliana I.

Summary: Mesenchymal stem cells (MSCs) have been known to have angiogenic potency, particularly for wound healing. However, it is such a cumbersome procedure to obtain a large amount of MSCs due to the culture process. The stromal vascular fraction (SVF), or so called nonexpanded MSCs, of adipose tissue is gaining increased interest in the field of cell therapy. An optimized method that takes only 2 hours to produce a large amount of stromal cells from adipose tissue has been developed. Burn wound model was used to assess the efficacy of SVF produced by our method. This study aimed to evaluate the efficacy of SVF compared to MSCs.

Research articles

Assessment of clinical judgment accuracy provided by emergency physicians in comparison with Peak Flowmetry in the severity and discharge criteria of patients with asthma attack

by Davood Sharifi M., Feiz Disfani H., Reza Rahmatzadeh H.

Summary: In the emergency department, the decisions on admission or discharge are based on clinical symptoms and physical examinations. The aim of this study is to compare the assessment of emergency physician clinical judgment accuracy with the actual amount of peak expiratory flow rate (PEFR).


Deciphering the role of AMPK-related kinase 5 in human cancer progression and metastasis

by Bambang A., Tanadi C., Sumarpo A.

Summary: Malignancies related mortality is currently growing at an alarming rate. Early detection of cancer is vital in order to improve survival rates of cancer patients, and biomarker detection is regarded as one of the most promising approaches. Recent studies have reported that elevated AMPK-related kinase 5 (ARK5) expression is associated with tumor progression and metastasis in several human malignancies. Several pathways are also influenced by the presence of ARK5, most notably the PI3k-Akt pathway, m-TOR phosphorylation, and several pathways that induce increased tumor invasion activity. Additionally, ARK5 expression are linked to miR-1181 down-regulation, which promotes epithelial mesenchymal transformation in ovarian cancer cells. Furthermore, ARK5 gene transcription is also affected by the interaction of c-MAF and MAFB with both MARE core sequences present in the ARK5 promoter. Based on the current evidences, ARK5 might be the master regulator of cancer progression and metastasis, which could potentially serve as a novel target for cancer therapies.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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