journal description

Biomedical Research and Therapy - The Vietnamese Journal of Biomedicine fully open access journal of original research across a broad spectrum of medical scientific disciplines and sub-specialties. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.

Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. 

The journal is published monthly, 12 issues per year.


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Research articles

The effect of regular aerobic activity on cortisol levels in female Wistar rats

by Ibrahimaj Gashi A., Azemi A., Zivkovic V., Gontarev S., Gjorgovski I.

Summary: Physical inactivity has been identified as a major risk factor for global mortality, causing approximately 2 million deaths globally, whereas the physical activity of moderate intensity has significant benefits for health. Exposure to stress results in changes in the endocrine and autonomic nervous systems, as well as behavioral changes which allow an organism to adapt to environmental changes. This study aimed to assess changes in cortisol levels and body temperature in rats after forced swim tests.

Research articles

The value of the Global Registry of Acute Coronary Events and Gensini scores in predicting long-term outcomes in Vietnamese patients with non-ST-elevation acute coronary syndrome

by Van Hoang S., Minh Nguyen K., Hoang Nguyen A., Le Anh Huynh K., Phuong Nguyen Tran H.

Summary: Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) should undergo risk stratification as soon as possible after their presentation. Early risk satisfaction provides good prognosis for patients as well as better decision for reperfusion therapy. The aim of this study is to find a correlation between the Global Registry of Acute Coronary Events (GRACE) risk score and severity of coronay artery disease assessed by Gensini score score and compare the value of GRACE and Gensini scores in predicting the long-term outcomes in patients with NSTE-ACS.


Evaluating the effectiveness of using enoxaparin to prevent venous thromboembolism in hip replacement patients: A retrospective cohort study

by Thanh Toan V., Dong Kha T., Van Anh B.

Summary: Our research aims to evaluate the effectiveness of thromboprophylaxis using enoxaparin in patients undergoing hip replacement.


Evaluation of renal cyst treatment using retroperitoneal laparoscopic decortication

by Ho U., Dam C., Le N.

Summary: Renal cyst is a common disease of the renal parenchyma. The management options include percutaneous aspiration with or without sclerotherapy, open surgery, and laparoscopic decortication of renal cyst. Laparoscopic renal cyst decortication is a safe and effective alternative with a high success rate. This study aimed to evaluate renal cyst treatment by retroperitoneal laparoscopic decortication.

Research articles

Effectiveness of elective single versus double frozen embryo transfer in good prognosis IVF patients

by Thanh T., Huy P., Linh D., Loc N., Duy N., Vinh D., Huyen N.

Summary: This study aimed to evaluate the effectiveness of elective single embryo transfer (eSET) versus double embryo transfer (DET) in frozen embryo transfer cycles following in vitro fertilization (IVF) treatment in good prognosis patients. The outcome would provide medical data for the multiple pregnancy rate reduction in IVF treatment.

Case report

Effect of drug-induced pathomorphosis on oral cavity organs and tissues in chronic obstructive pulmonary disease combined with coronary heart disease: A clinical case

by Emelyanova N., Komir I.

Summary: This article describes a clinical case of a patient, as well as literature data confirming the direct mutual influence of lesions in the oral cavity and the bronchocardiac complex pathology. Special attention is paid to the side effects of the main drugs prescribed in the basic therapy of chronic obstructive pulmonary disease, combined with coronary heart disease. It is noted that the drug-induced pathomorphosis can cause the development of periodontal lesions. Insufficient knowledge of these issues and the practical need for corrective measures to be taken by dentists with this category of patients warrant the relevance of research in this direction.


Concise review: The role of cancer-derived exosomes in tumorigenesis and immune cell modulation

by Thao Huynh N., Duy Pham K., Chau Truong N.

Summary: Exosomes are subcellular entities which were first discovered in the 1980s. Over the past decade, scientists have discovered that they carry components of genetic information that allow for cell-cell communication and cell targeting. Exosomes secreted by cancer cells are termed cancer-derived exosomes (CDEs), and play an important role in tumor formation and progression. Specifically, CDEs mediate the communication between cancer cells, as well as between cancer cells and other cells in the tumor microenvironment, including cancer-associated fibroblasts, endothelial cells, mesenchymal stem cells, and effector immune cells. Additionally, through the vascular system and body fluids, CDEs can modulate response to drugs, increase angiogenesis, stimulate proliferation, promote invasion and metastasis, and facilitate escape from immune surveillance. This review will discuss the relationship between cancer cells and other cells (particularly immune cells), as mediated through CDEs, as well as the subsequent impact on tumorigenesis and immunomodulation. Understanding the role of CDEs in tumorigenesis and immune cell modulation will help advance their utilization in the diagnosis, prognosis, and treatment of cancer.


Current strategies for adoptive immunotherapy for cancer: ”Off-the-shelf” immune cells

by Ngo Trong H., Le Van Manh H., Thanh Dang V., Ho-Thao Nguyen N., Vu Thanh B., Pham P.

Summary: Immunotherapy, especially immune cell-based therapy, is a strategy for cancer treatment that has over the past decades focused on novel modifications and targets. In recent years, adoptive cell immunotherapy has continuously evolved, with studies of different platforms utilizing different immune effector cells to kill a variety of cancer cells. This review summarizes the various kinds of immune cells which have been used in adoptive cell therapy (ACT), including natural killer cells, cytokine-induced killer cells, T cells, and engineered immune cells. Most reports have shown that ACT can induce tumor regression, both in animal studies and clinical trials. However, the high cost of ACT is the greatest disadvantage of this strategy. Moreover, the efficacy of treatment is variable among patients. To reduce these disadvantages, off-the-shelf immune cells are considered the best solution to reduce the cost while maintaining the efficacy of treatment. In this review, we will discuss the potential of various kinds of immune cells for development as ``off-the-shelf'' immune cells for use in adoptive cell therapy, based on their unique advantages.


A retrospective analysis of pyogenic liver abscess and antibiotic resistivity of common pathogens in Peshawar

by Bashir N., Adnan Shereen M., Kazmi A., Sajid M., Ullah H.

Summary: Pyogenic liver abscess (PLA) is a rare but life-threatening disease, with a frequency ranging from 10.83 to 17.45 per 100,000 persons. The major cause of PLA is bacterial infection of liver parenchyma. The present research study was designed to investigate the common microbes causing PLA in Peshawar (Pakistan) and to evaluate a variety of the most capable and efficient antibiotics for treatment of PLA.

Research articles

A simple and scalable method to generate spheroids from human mesenchymal stem cells for use in tissue engineering

by Vu N., B., Nguyen M. T.-N.

Summary: Tissue engineering is a field suited for applying stem cells, besides stem cell transplantation. In the current tissue engineering approaches, stem cells are typically seeded onto a suitable scaffold and induced into specific tissues under particular conditions. However, this strategy has faced some limitations, namely that stem cell proliferation on the scaffolds' surface has been inefficient to fill the porous scaffolds to produce solid tissues. Some limitations have been improved by using stem cell spheroids on the scaffold in place of single stem cells. This study aimed to evaluate a simple and feasible method to produce spheroids of mesenchymal stem cells (MSCs) from adipose and umbilical cord tissues for use in tissue engineering.

Research articles

The effects of analytic group therapy compared with pharmacotherapy in patients with anxiety disorders

by Sedighi S., Rahmani S., Moinolghorabaei M.

Summary: Psychotherapy and pharmacotherapy are both effective in the treatment of anxiety disorders. However, drugs in pharmacotherapy are often compared with placebo controls, and psychotherapy is mostly compared to patients in the waiting list as the controls. We aimed to compare the effects of analytic group therapy with pharmacotherapy in patients with anxiety disorders.


Correction to: Quenching of singlet oxygen by natural and synthetic antioxidants and assessment of electronic UV/Visible absorption spectra for alleviating or enhancing the efficacy of photodynamic therapy

by Fatima K., Masood N., Luqman S.

Summary: The original article1 contains an error in the author affiliation. The author affiliation is corrected as below:

Research articles

Gastric cancer in East Azerbaijan, Iran: Five-year survival analysis of population-based cancer registry results

by Jabbaripour P., Somi M., Abdolahi H., Dolatkhah R.

Summary: Gastric cancer is the most common cancer with significant increasing trends during the last decade in Iran. The aim of this study was to evaluate the epidemiologic profile of gastric cancer along with gastric cancer-specific survival analysis.


The role of tumor-derived exosomes in tumor immune escape: A concise review

by Truong N., Huynh T., Pham K., Pham P.

Summary: Exosomes are small vesicles secreted by viable cells into the microenvironment. These vesicles bring various compositions, including lipids, RNAs and proteins, which carry information from producer cells to target cells. Cancer cells also produce exosomes, termed as tumor-derived exosomes (TDEs), which play important roles in immune modulation, angiogenesis and metastasis of tumors. This review summarizes the roles of TDEs in tumor immune escape mechanisms. TDEs affect all kinds of tumor-associated immune cells, including natural killer (NK) cells, dendritic cells (DCs), T and B lymphocytes, and myeloid-derived suppressor cells (MDSCs). Generally, TDEs suppress the immune system to promote tumor immune escape, thereby significantly contributing to tumorigenesis and metastasis.



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Stem Cells and Regenerative Medicine
The collections of published articles about stem cells as well as regenerative medicine. 
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Special Issues 

Special Issues 
Biomedical Research and Therapy would like to invite guest editors to contribute special issue. 
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Natural Extract
The collections of published articles about herbal, natural products. 
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The best original research articles
Every year, all authors published their studies as Original research in Biomedical Research and Therapy can join this awards.
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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

Why publish with Biomedical Research and Therapy




Aims & Scope of Biomedical Research and Therapy updated


Biomedical Research and Therapy (ISSN 2198-4093) was published by Springer in Global Science Journals from 2014-2015, and BioMedPress from 2016 to now. As a result of a revolution, and to improve the journal quality, the publisher decided to revise the aims and scope of Biomedical Research and Therapy.

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Copyright 2014-2018 BioMedPress. This work is licensed under a Creative Commons Attribution 4.0 License. A partner of HINARI, AGORA, OARE, Crossref