Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease and its correlation with disease severity
Serum hsCRP is higher in the COPD group than the control group matched based on age, and hsCRP is correlated with the severity of COPD. Further studies with larger sample sizes are required for evaluating this correlation in patients with COPD....
Mesenchymal stem cells accelerate liver regeneration in acute liver failure animal model
The study showed an significant (P<0.001) increase of PDGF and VEGF levels on the 2nd day, followed by a decrease on the 7th day, along with a decrease of SGPT and SGOT levels as well as the normality of histology appearance.....
Mesenchymal stem cells for diabetes mellitus treatment: new advances
MSC transplantation in preclinical trials and clinical trials for T1DM and T2DM have shown a moderate to significant improvement in diabetes without adverse side effects. In this review, we will discuss some of the updates from preclinical and clinical trials of MSC transplantation for diabetes....
Antibacterial cellulose-based aerogels for wound healing application: A review
Summary: Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.
Microcirculatory effects of systemic metabolic correction with reactive oxygen species: An experimental study
Summary: The purpose of this study is to estimate microcirculation changes under systemic (intraperitoneal) administration of ozonized saline.
Convalescent plasma successfully treats a severe COVID-19 patient with multi-organ failure
Summary: Due to the high mortality rate of coronavirus disease 2019 (COVID-19) and the lack of specific treatment for the disease, it is essential to find new therapies. The present case report aimed to assess the efficiency of convalescent plasma in patients with severe acute respiratory syndrome coronavirus 2. We reported a severe case of COVID-19 with multi-organ failure, who had reduced oxygen saturation after several courses of antiviral therapy. Moreover, computed tomography (CT) scan results showed patchy lesions in the base of lungs. Therapeutic measures, including endotracheal intubation and plasmapheresis with convalescent plasma, were performed for the patient; subsequently, good responses to the treatments were observed. Our findings demonstrate that convalescent plasma improves pulmonary lesions and the patient's clinical status.
Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry
Summary: Cumin (Cuminum cyminum L.) is an annual plant that is not only one of the most popular seed species but also one of the oldest and most cultivated aromatic and herbaceous natural products with numerous medicinal, nutraceutical, and pharmaceutical properties. It is widely used in the beverage, food, liquor, medicine, perfume, and toiletry industries. The objective of this work was to provide a precise and up-to-date review of the ethnopharmacology, phytochemistry, and biological activities of cumin.
Preterm birth and low birth weight in neonates with postnatal respiratory failure at a tertiary hospital in Viet Nam
Summary: This study aimed to evaluate the rate of preterm birth and low birth weight in neonates having postnatal respiratory failure.
The APC gene rs41115 polymorphism is associated with survival in Iranian colorectal cancer patients
by Mir Najd Gerami
Summary: The onset of colorectal cancer is a complex process caused by numerous genetic pathways. APC functions as a ``"gatekeeper" and its mutations occur at the initiation stage of the colorectal tumorigenesis. The main aim of this study was to investigate common somatic mutations of exon 15 APC genes in patients with colorectal cancer in East Azerbaijan, Iran.
The effect of low-level laser therapy on quality of life in postmastectomy lymphedema patients
Summary: In this study, the aim was to evaluate the effect of low-level laser therapy (LLLT) on quality of life in postmastectomy lymphedema (PML) patients.
Anatomical indicators of the heart and coronary arteries: An anthropometric study
Summary: Previous studies confirm that there is no anthropometric index of normal Iranian hearts, including diameter of cardiac valve, thickness of myocardial septum and coronary artery variation. The purpose of this study was to assess the anatomical indexes of the human heart and coronary artery in the Iranian population.
Clinical and functional predictors that cause a decrease of indicators of morning blood pressure profile in antihypertensive telmisartan-based therapy
Summary: Blood pressure (BP) monitoring is an important aspect in the treatment of arterial hypertension (AH), namely the morning BP increase which is associated with an increased risk of cardiovascular and cerebrovascular incidents as well as sudden death. The study herein revealed clinical and functional predictors which decrease the morning BP rise in the case of optimal antihypertensive therapy with telmisartan, based on results of daily blood pressure monitoring (DBPM).
Clinical symptoms, endoscopic imaging and stroboscopic imaging in patients with laryngeal fungal infection : An evaluation in 48 patients
Summary: Aspergillus fumigatus and Candida albicans are the most common pathogenic fungi found in Vietnam. Fungal laryngitis has yet to be thoroughly investigated due to the rarity of the disease. This study aimed to describe the clinical, endoscopic and stroboscopic imaging characteristics among patients with fungal laryngitis.
Analgesic and anti-inflammatory activity of aqueous extract of Bubonium graveolens
Summary: Bubonium graveolens is used in traditional pharmacopoeia against imbalances of the gastrointestinal tract, cephalic pains, and bronchitis, and as an anti-inflammatory agent.
Expression of P16 biomarker in squamous cell carcinoma of uterine cervix and its association with clinico-pathological parameters: A cross-sectional study
Summary: Cervical cancer is the most common cancer among females. P16 is the surrogate marker for cervical carcinoma. This study aimed to evaluate the association of P16 marker with clinic-pathological parameters in squamous cell carcinoma of uterine cervix.
Novel immunogenomic insights of corona virus disease (COVID-19): Available potential immunotherapeutics, current challenges, immune cell recognition and ongoing managerial strategies
Summary: The emerging Corona virus strain (severe acute respiratory syndrome corona virus-2 (SARS-CoV-2)) harbors intricate in the development of corona virus infection (COVID-19)-induced pneumonia and subsequently ameliorates lung infection. Genome sequence and interventions reveal proximal resemblance of corona virus strain COVID-19 with severe acute respiratory syndrome (SARS), transmittable to bats, suggesting similar primary hosts in the spread of infection. However, potential rapid human-to-human transmission has caused therapeutic challenges in treating a wide range of humans suffering from corona virus all over the world. However, up to now, no direct vaccines or antiviral drugs are available to treat COVID-19. Previously designed antiviral drugs and convalescent plasma are undergoing investigations as treatment for COVID-19 infected patients. Therapeutic challenges with regards to COVID-19 have prompted scientists to develop fruitful remedies to combat the pathogen. In this review, we address the role of current ongoing therapeutic strategies, , and complex mechanisms of adaptive immune system (B and T cells) to respond to viruses. Furthermore, we illustrate the current challenges in the treatment of COVID-19, managerial strategies, and ongoing and future perspectives.
Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?
Summary: The most common malignancy which endangers the quality of life in females is breast cancer. It is also the major public problem in society and despite advances in treatment strategies, it still leads to high mortality. In all breast cancer patients, the first assessment done before surgery is the complete blood count (CBC). There exists a strong relationship between immune response of the body and clinical staging of breast cancer. This study aimed to determine the most reliable hematological markers for the prognosis of breast cancer, and to evaluate the correlation between hematological parameters and disease staging.
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Phuc Van Pham, Editor-in-Chief
Why publish with Biomedical Research and Therapy
Biomedical Research and Therapy (ISSN┬á2198-4093) was published by Springer in Global Science Journals from 2014-2015, and BioMedPress from 2016 to now. As a result of a revolution, and to improve the journal quality, the publisher decided to revise the aims and scope of Biomedical Research and Therapy.
On behalf of Editor-in-Chief Phuc Van Pham, we are pleased to announce that Biomedical Research and Therapy is seeking qualified candidates who are willing to serve, if elected, in the position of Editorial Board Member.