journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. 

Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

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Featured Articles

latest articles


SARS-CoV-2 pandemic: causes and current situation, historical lessons, and strategical therapeutic interventions

by Shereen M., Kazmi A.

Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused an initial outbreak in China, now has 40 strains with infections in more than 200 countries worldwide, according to scientists. To date, 4,121,777 people have become infected and 280,868 people died as a result of coronavirus disease 2019 (COVID-19), with many patients still under critical condition. The SARS-CoV-2 is phylogenetically similar to SARS-like bat viruses and, thus, bats can be a key host for SARS-CoV-2. Many viruses have been transmitted to humans due to the consumption of wild birds and animals as a food source. The lack of vaccine, improper containment, and diagnostic strategies by various countries have converted COVID-19 into a global pandemic. The lockdown conditions in developing countries may produce economic crises. COVID-19 patients can suffer from mental distress, partly resulting from quarantine restrictions, and therefore, there is dire need for mental counseling. The combination of previously used broad-spectrum antibiotics, antiviral and anti-parasite agents, and interferon have reduced viral infection at higher and frequent doses. Many patients have been discharged after clinical recovery, though COVID-19 can still leave severe adverse effects on patients. The use of traditional Chinese medicines (TCMs) has led to recovery of 90% of COVID-19 patients in China. The current review article highlights the current situation, the major causes which have led to the COVID-19 pandemic, as well as strategical interventions to control the pandemic and cure infected patients.

Research articles

The effects of monocusp valve implantation and transannular patch angioplasty on pulmonary regurgitation and right ventricular failure after total correction of tetralogy of fallot

by Samadi M., Khoshfetrat M., Keykha A., Javadi S.

Summary: Pulmonary regurgitation (PR) is often known as an acquired condition after surgical correction of tetralogy of Fallot (TOF). Therefore, the present study aimed to compare the use of monocusp valve (MV) implantation and transannular patch (TAP) angioplasty on PR and right ventricular (RV) failure following surgery to repair TOF.

Research articles

Prophylactic treatment of ischemic stroke with Coffea arabica in rats: A preliminary study

by Khanum A., Shakir L., -ur-Rehman Z., Khan T., Najam K., Saeed N., Khan M., Nazeer A., Nazir T., Aslam S.

Summary: Ischemic stroke is the third leading cause of death worldwide. The purpose of the current study was to assess the preliminary effects of Coffea arabica (CA) in experimentally-induced stroke in an animal model in the context of neuroprotection. The study was also designed to document the prophylactic use of CA in patients experiencing stroke symptoms.

Research articles

The predictive value of vascular endothelial growth factor-A gene polymorphism for clinical outcomes among acute ST-segment elevation myocardial infarction patients: A single center prospective study

by Kutia I., Kopytsya M., Hilova Y., Petyunina O., Berezin A.

Summary: Vascular endothelial growth factor (VEGF) is an angiopoetic factor; its variability in circulating levels is mediated by expression of specific VEGF-A gene variants. The aim of this study was to investigate the predictive role of VEGF-A gene polymorphism in clinical outcomes of STelevation myocardial infarction (STEMI) patients.

Case report

Association of a point mutation (m.9176T>G) of the MT-ATP6 gene with Leigh syndrome: A case report

by Khailany R., Gilani N., Ozaslan M., Safdar M., Al-Shamari I., Kanabe B., Saadat K., Homayounvash J., Monfaredan A., Al-Attar M., Arslan A.

Summary: Leigh Syndrome (LS) is an uncommon progressive neurodegenerative mitochondrial disorder. The condition is characterized by progressive mental and developmental disabilities (psychomotor regression) and commonly brings about death within a few years of diagnosis, more often due to respiratory failure. In a small number of patients the disorder does not manifest until adulthood. The principal indications of Leigh syndrome found in early stages typically are diarrhea, vomiting, and difficulty swallowing (dysphagia), which disturbs eating. These problems usually result in powerlessness to develop and put on weight under the normal rate (failure to thrive). Serious movement and muscle problems are basic in Leigh syndrome. In this case report, we introduce the molecular and clinical features of a 19-year-old female as proband, and also, we study other members of the family consequently. The m.9176T>G heteroplasmic mutation in the MT-ATP6 gene was detected by high-resolution melt (HRM) and DNA sequencing techniques. Similarly, the m.9176T>G was heteroplasmic in the mother. In conclusion, this report in compliance with previous studies underlines the necessity of further research on prenatal distinguishing proof of the responsible mutations and avoidance of the disease in families with known cases.

Short Communication

Comparison between preoperative and post-operative administration of paracetamol, ibuprofen and mefenamic acid for post-extraction pain control

by Kumar G., Shu-Lyn C., Win G., Sie L., Lakman N., F., Haque N.

Summary: Pain is a common aftereffect following a dental treatment, especially extractions. Hence, the main aim of the study was to compare the effect of pre-operative and post-operative analgesic usage on post-operative pain management following dental treatment. Moreover, the efficacies of three types of painkillers (Paracetamol, Ibuprofen and Mefenamic Acid) in pain relief were also evaluated. Volunteers (n = 120) who were undergoing extraction participated in this study and were randomly divided into two groups. One group consisting of 60 participants were given pre- and post-operative analgesics while another group (n = 60) received post-operative analgesics only. A visual scale was used to record pain from zero to 56 hours post-operatively at 8-hour intervals. The results showed that patients who were taking analgesics pre-operatively experienced significantly (p = 0.0045) less pain compared to those who had taken post-operative analgesics only However, a lower cumulative number of moderate and severe experiences of post-extraction pain was recorded for the pre- and post-operative analgesic treatment groups as compared to the postoperative only analgesic treatment group; no significant differences were observed. Moreover, no significant differences were observed among the analgesics used in this study as well. On the basis of these results, we conclude that preoperative analgesic usage has a positive impact on postextraction acute pain management.

Research articles

Analgesic, anti-inflammatory and hypouricemic effects of GT1 film-coated tablets on experimental animals

by Tuyen P., Huyen T., Phong P., Thong N., Hang D., Anh P.

Summary: To evaluate pain relief, anti-inflammatory and hypouricemic effects of GT1 tablets on experimental animals.

Research articles

Acalypha wilkesiana ‘inferno’ hydroethanolic leaf extract has protective effect on carbon tetrachloride-induced subacute toxicity in animals

by Larbie C., Emikpe B., Oyagbemi A., Nyarko R., Jarikre T., Adjei C., Aseidu E.

Summary: Liver fibrosis is one of the most common clinical manifestations of hepatic diseases. However, though many synthetic drugs exist for the treatment and prevention of liver diseases, liver injuries still persist. The present study, therefore, sought to investigate the subacute protective effects of Acalphya wilkesiana against carbon tetrachloride (CCl4)-induced toxicity in animals.

Research articles

Investigating the histopathological effects of saffron petal (Crocus Sativus L.) hydroalcoholic extract on kidney and liver functional parameters in rats

by Azizi M., Ahmadi M., Mohamadpour M., Daemi A., Asadi S., Shirzadpour E., Amraei M.

Summary: Saffron is one of the main food products in Iran, and its countless medicinal properties have been used widely in traditional medicine. Many studies conducted and reported in the literature have shown that plant-based medicines, such as chemical drugs, may also have unexpected side effects. Thus, the present study aimed to investigate the histopathological effects of the hydroalcoholic extract of the saffron petal (HAESP) on the liver and kidney, particularly on their functional parameters in rats.

Research articles

Comparison of injection of midazolam-fentanyl with pethidine in management of pain induced by extracorporeal shock wave lithitripsy: A randomized clinical trial

by Kameli A., Haghighi R., Marhamati M., Zarei M.

Summary: Urinary stones are the third most common disease of the genitourinary tract after urinary tract infections and prostate diseases. One of the ways to remove a urinary stone is extracorporeal shock wave lithitripsy, which crushes the stones for easier removal, and it is often used to reduce pain, reduce anxiety, and stabilize the patient. In this regard, the use of effective analgesics with less serious side effects seems reasonable.


Nutrition and osteoporosis prevention and treatment

by Hejazi J., Davoodi A., Khosravi M., Sedaghat M., Abedi V., Hosseinverdi S., Ehrampoush E., Homayounfar R., Shojaie L.

Summary: Osteoporosis falls among the major general health issues, specifically in the elderly, and is a widespread disease these days. According to various studies, good nutrition plays a significant role in osteoporosis prevention and treatment. The aim of this study was to conduct an extensive literature review on the effects of different nutrients to understand how macronutrients, micronutrients, and non-nutritive substances affect bone health.


Method for in vitro production of cartilage microtissues from scaffold-free spheroids composed of human adipose-derived stem cells

by Tu V., Le H., To X., Nguyen P., Huynh P., Le T., Vu N.

Summary: Cartilage damage is one of the injuries that is difficult for the human body to self-repair due to the avascular and completely mature tissue with only few stem or progenitor cells present. Recently, some studies showed that engineered cartilage tissues could be used to treat or improve this injury. This study aimed to produce the cartilage microtissues from the differentiation of scaffold-free spheroids composed of human adipose-derived stem cells.


Reported Polio cases in Pakistan during 2019

by Ahmad T., Haroon H., Hussein Musa T., Khan M., Baig M., Ning F.

Summary: This report describes polio cases, vaccination uncertainty and challenges, and the way forward to eradicate polio from Pakistan. Numerous articles, government and non-government documents, and survey reports were studied and an online search was made to collect information on polio in Pakistan. Once again the polio vaccination program has been stopped and accused by the local community in Pakistan as a result an increase has been seen in polio cases in the last year. In 2019, a total of 117 wild poliovirus (WPV) and 18 circulating vaccine-derived poliovirus (cVDPV2) cases were reported from the country. The majority of cases were from the Khyber Pakhtunkhwa (KP) province as a result of polio vaccination uncertainty and many challenges faced by the vaccination program in the region. Pakistan reported their highest annual number of WPV cases as compared to last few years. This increase is not only an alarming threat for the country but also a key challenge for the global polio eradication movement. Increase awareness and raising immunization to over 100% in some areas especially in the remote area where every year many children missed vaccination to achieve global polio eradication goals.

Research articles

A comparison of in vitro fertilization-embryo transfer outcome by two types of soft embryo transfer catheters

by Rabiei S., Yavangi M., Farimani M., Amiri I., Fallah M., Bahrami H., Khansari S.

Summary: One of the remaining challenges in assisted reproductive procedures, especially in vitro fertilization (IVF), is proper embryo transfer. The aim of this clinical trial was to compare IVFembryo transfer outcome by two types of soft embryo transfer catheters in Hamadan Endometrics and Endometriosis Research Center (Iran).



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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