Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease and its correlation with disease severity
Serum hsCRP is higher in the COPD group than the control group matched based on age, and hsCRP is correlated with the severity of COPD. Further studies with larger sample sizes are required for evaluating this correlation in patients with COPD....
Mesenchymal stem cells accelerate liver regeneration in acute liver failure animal model
The study showed an significant (P<0.001) increase of PDGF and VEGF levels on the 2nd day, followed by a decrease on the 7th day, along with a decrease of SGPT and SGOT levels as well as the normality of histology appearance.....
Mesenchymal stem cells for diabetes mellitus treatment: new advances
MSC transplantation in preclinical trials and clinical trials for T1DM and T2DM have shown a moderate to significant improvement in diabetes without adverse side effects. In this review, we will discuss some of the updates from preclinical and clinical trials of MSC transplantation for diabetes....
Clinical data analysis of dengue fever severity identification
Summary: The dynamic nature of dengue fever demands rapid and repeated clinical detection based on the vital signs variables, blood profile, and symptoms for providing timely clinical treatment. Patients with or without warning signs are at risk of contracting the severe dengue; thus, this study aims to identify the vital signs and blood profile variables that would differentiate the severity levels of dengue fever among dengue patients.
Disorders of proteolytic homeostasis in the liver of rats with hyperhomocysteinemia
Summary: The liver is a key organ of the body that is responsible for maintaining homeostasis. It helps regulate almost all biochemical pathways associated with metabolism, nutrition, energy supply, and the formation of immunity. Consequently, impaired liver function can contribute to the progression of hyperhomocysteinemia and the development of associated complications. The present study aims to investigate the level and activity of metal-dependent and serine proteases in the liver of rats with hyperhomocysteinemia.
Transplantation of mesenchymal stem cell sheet to treat acute hind-limb ischemia: A preclinical study
Summary: Mesenchymal stem cell (MSC) transplantation has been reported as a promising therapy for acute limb ischemia (ALI). However, the treatment efficacy is limited to only certain improvements. Therefore, this study aims to improve the treatment efficacy of MSC transplantation through the use of MSC sheets produced from MSCs' cultured in fibrin scaffold (Fi-MSCs) in ALI models.
Preclinical toxicological evaluation of measles virus vaccine strain in non-human primates: A two-month intravenous study
by Thanh Chung
Summary: Based on its ability to kill tumor cells, the vaccine strain of the measles virus is used for oncolytic virotherapy. However, the dose required for cancer therapy is much higher than that used for vaccination. Therefore, this study was conducted to evaluate the preclinical toxicology of the vaccine strain of measles virus in monkeys.
Pachyonychia Congenita Type PC-K6a: The first report in the Vietnamese population
Summary: Pachyonychia congenita (PC) comprises a group of rare autosomal dominant genetic disorders. It is characterized by hypertrophic nail dystrophy, focal palmoplantar keratoderma, follicular keratosis, and oral leukokeratosis. It is associated with mutations in five differentiationspecific keratin genes: KRT6A, KRT6B, KRT6C, KRT16, or KRT17. The case is being reported for its rarity. To the best of our knowledge, this is the first report of PC, from Vietnam, confirmed by genetic analysis.
Mechanisms in Tridax procumbens leaf extract reversal of paroxetine-induced erectile dysfunction in corpus cavernosum of male Wistar rats
Summary: Aqueous leave extract of Tridax procumbens (AETPL) is reported to improve erectile functions; however, the mechanism is unclear. This study investigates the mechanism involved in the contractile activity of the corpus cavernosum after AETPL treatment of paroxetine-induced erectile dysfunctional adult male Wistar rats.
Neutrophilsâ€™ functional activity in patients with mechanical jaundice and different levels of bilirubin
Summary: Mechanical jaundice (MJ) or bile duct blockage occurs when the bile ducts' patency is impaired, and the bile flow has stopped. One of the main pathogenetic factors developing complications with MJ is immune system imbalance, particularly its phagocytic link. The purpose of the study was to understand neutrophils' functional activity dependence with different blood bilirubin levels in men with mechanical jaundice.
Conditioned media from human adipose-derived stem cell culture in some stressed culture conditions differ angiogenic potential
Summary: The potency of mesenchymal stem cells (MSCs) related to their biological effects includes immune modulation and angiogenesis. Recently, some stress conditions were applied to enhance the angiogenic potential of MSCs. This study aimed to assess the effects of conditioned media (CM) collected from adipose-derived stem cellsâ€™ (ADSCsâ€™) culture under various stress conditions on angiogenesis in vitro.
Vitamin D and COVID-19: A Physiological Perspective
Summary: Known for its ability to enhance the performance of the immune system, preclude microbial infections, and reduce susceptibility to influenza, Vitamin D (or 1,25-dihydroxyvitamin D (1,25(OH)2D) as the active form) has garnered a positive reputation in the management of COVID-19 for some time. Its deficiency is statistically correlated with infection of the disease, as well as disease severity and fatalities. There have been suggestions that Vitamin D supplements could either prevent the contraction of SARS-CoV-2, the coronavirus which causes the disease or alleviate the symptoms of the disease. Indeed, data have established a relationship between Vitamin D supplementation and the severity of respiratory illnesses, with some assays indicating optimistic results in COVID-19 patients who were supplemented with the vitamin. Accordingly, a great deal of research and efforts have been put into investigating the physiological mechanisms in the human body attributable to the vitaminâ€™s reputation against the coronavirus. Combined with what was already discovered before the advent of SARS-CoV-2, a great amount of knowledge has consequently now been unveiled. Via regulation of various pathways, 1,25(OH)2D promotes the production of antimicrobial peptides, autophagy, as well as integrity and impermeability of cellular junctions against pathogens. Moreover, it mitigates the consequences of SARS-CoV-2 infection, such as cytokine storm (through immunomodulation of T cell differentiation pathways) and lung injury (through stimulation of the Angiotensin-Converting Enzyme 2 (ACE2) and manipulation of the Renin-Angiotensin System (RAS)). Nevertheless, Vitamin D deficiency still plagues the global population across all age groups, possibly contributing to the heightened global exposure to the coronavirus. With the COVID-19 pandemic inexorably raging on with no prospect of termination observable in the foreseeable future, this review article provides a concise yet thorough insight into the vast knowledge which could illuminate the significance of Vitamin D amidst the current predicament experienced by mankind, as well as instigate further curiosity and ignite further investigations into the role of vitamins, such as Vitamin D, as a safeguard against SARS-CoV-2.
Immunological and mutational analysis of SARS-CoV-2 structural proteins from Asian countries
Summary: The emergence of a novel coronavirus, SARS-CoV-2, an etiologic agent of coronavirus disease (COVID-19), has led to a pandemic of global concern. Considering the huge number of morbidity and mortality worldwide, the World Health Organization declared, on 11th March 2020, the pandemic as an unprecedented public health crisis. The virus is a member of plus sense RNA viruses that can show a high rate of mutations. The ongoing multiple mutations in the structural proteins of coronavirus drive viral evolution, enabling them to evade the host immunity and rapidly acquire drug resistance. In the present study, we focused mainly on the prevalence of mutations in the four types of structural proteins- S (spike), E (envelope), M (membrane), and N (nucleocapsid)- that are required for the assembly of a complete virion particle. Further, we estimated the antigenicity and allergenicity of these structural proteins to design and develop a potentially good candidate vaccine against SARS-CoV-2.
Effect of rose extract treatment on soluble CCR5 and CXCR4 secretion by the endothelial cells in vitro
Summary: CC-Chemokine Receptor 5 (CCR5) and Chemokine C-X-C-Motif Receptor 4 (CXCR4) are expressed in various tissues, and they are potential molecules involved in multiple pathways. CCR5 and CXCR4 targets are associated with immune regulation in patients in multiple tissues and numerous clinical conditions. The study was performed searching for a novel therapy for immune regulation on these CCR5 and CXCR4 receptors with rose extract.
Morphokinetic parameters comparison between euploid and aneuploid blastocysts
Summary: Pre-implantation genetic testing for aneuploidy (PGT-A) has been using for years in embryoselection. However, this is an invasive method and may cause harm to the embryos. Therefore, time-lapse monitoring has been thought to be an alternative approach for embryo selection due to its efficiency. Up to now, several studies were investigating the relationship between the morphokinetic parameters and the embryo ploidy. However, the results are not consistent. This study aims to evaluate the correlation between morphokinetic parameters and PGT-A results.
Characterization of white matter branching in human cerebella: quantitative morphological assessment and fractal analysis of skeletonized MR images
Summary: The aim of the present study was to investigate branching characteristics of the human cerebellar white matter by the means of findings obtained from the quantitative morphological assessment and fractal analysis of the skeletonized MR images of the human cerebellum.
In vivo study of wound healing processes in Sprague-Dawley model using human mesenchymal stem cells and platelet-rich plasma
Summary: Mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) have a potential role in improving wound healing processes. This experimental study aims to compare PRP and MSCs to promote the wound healing process in the animal burn wound model.
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