journal description

Biomedical Research and Therapy publishes 12 peer-reviewed issues per year in all fields of biomedical and clinical sciences for internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Research and Therapy does not charge for subscription, submission, processing, or publication of manuscripts, nor for color reproduction of photographs. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics.

The journal is indexed and abstracted by ESCI  (Web of Science, Clarivate Analytics). Journal Citation Indicator (2020): 0.16

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Research articles

Evaluation effects of ascorbic acid leads to activate and induce osteogenic protein marker expression: in silico and in-vitro study

by Rosadi I., Indrady F., T., Karina K., Hariani N.

Summary: Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into several cell types including chondrocytes and osteocytes. The process of differentiation into such tissues is aided by transcription factors and collagen gene markers. Collagen biosynthesis is influenced by the presence of vascular endothelial growth factor (VEGF) and ascorbic acid cofactors of the prolyl hydroxylase 2 (PHD2) enzyme found in human cell receptors. The focus of this study is evaluation of how in silico methods can elucidate the effect of ascorbic acid on PHD2 and its expression. This study aimed to evaluate the role of ascorbic acid in its interaction with PHD2 (in silico) and the expression of type 1 collagen (COL1), type 2 collagen (COL2), and VEGF.

Case report

Long QT syndrome: Identification of a novel de novo mutation of calmodulin in a newborn girl

by Nguyen T., H., N., Bui C., B., Nguyen V., T., V., Nguyen M., C., Vu N., T., T., Nguyen M. H.

Summary: Long QT syndrome (LQTS) is a genetically and phenotypically heterogeneous disorder of ventricular myocardial repolarization that is typically characterized by prolongation of the heart rate-corrected QT interval on a 12-lead electrocardiogram (ECG). LQTS has a complicated etiology since great genotypic and phenotypic overlapping among LQTSs limits the establishment of a diagnosis based solely on clinical features.

Case report

Mature Placental Teratoma: A Case Report

by Khormoji N., Soleimani V., Sheikhhasani S.

Summary: Placental teratoma is an uncommon, non-trophoblastic benign tumor. Since the first description of this type of tumor by Morvilli in 1925, only a few cases of this abnormality have been diagnosed and reported.

Case report

A Rare Case of Pseudoaneurysm and an Arteriovenous Fistula of the Lumbar Artery Treated by Endovascular Intervention

by Dung L., Duc N., My T.,-T., Luu D., Linh L., Chau T.

Summary: Traumatic lumbar artery injuries are quite uncommon, and arteriovenous fistula (AVF) lesions are also rare. The clinical symptoms associated with AVF of the lumbar artery are often vague and non-specific and can be masked by symptoms due to the spinal cord injury. Therefore, AVF of the lumbar artery can often be missed if the performance of a contrast-enhanced computed tomography (CECT) scan is absent. In this article, we portrait a case of post-traumatic lumbar artery AVF along with pseudoaneurysm in a 40-year-old who suffered from pain in the right lumbar region. After endovascular intervention therapy for one month, the Visual Analogue Scale (VAS) was 1 in comparison with 8 prior to treatment. Thus, an endovascular intervention should be considered an effective treatment option for AVF and pseudoaneurysm of the LA.

Research articles

Generation of Bacillus subtilis displaying alpha-toxin HlaH35LH48L fused with CotB and CotG, and studying the immune response in mice

by Nguyen N., Duong L., Truong D., Nguyen T., Nguyen A., Nguyen T., Nguyen U., Dinh T., Thanh D., Nguyen H.

Summary: The Bacillus subtilis spore is considered to be a powerful vehicle for surface display and antigen delivery. Being safe and widely used for the purpose of oral bacteriotherapy in humans and animals, B. subtilis spore has potential in the domain of needle-free vaccine development. The spores themselves also behave as an adjuvant. This study aims to generate B. subtilis spores expressing mutant staphylococcal alpha-toxin HlaH35LH48L on the surface and to study their ability to evoke a specific immune response in mice.

Research articles

Diabetic dyslipidemia: A screening tool for cardiovascular risk assessment

by Ali S., Rao N., Amir S.

Summary: Dyslipidemia is the most common threat in connection to developing cardiac disorders in type two diabetes mellitus. It has a role in the eventual development of atherosclerosis and increased mortality and morbidity. The present study was conducted to determine the lipoprotein abnormalities found in type two diabetic patients in the Mangalore region in South India.

Research articles

Elevated expression of SKP2 correlates with poor prognosis in osteosarcoma: a bioinformatics analysis

by Hoang T.,-M., Nguyen M.,-T., Chen W., Zhuang C., Wang Z., Wang H., Li J., Lin H.

Summary: Osteosarcoma (OS) is the most prevalent kind of bone cancer, but the tumorigenesis and underlying molecular drivers of OS remain unknown. The instability of the cell cycle regulation system, which leads to uncontrolled cell proliferation, is a typical characteristic of carcinogenesis. This study aimed to investigate the expression of SKP2 in human OS and assessed its prognostic value in OS patients.

Case report

Identification of a novel de novo deletion mutation of desmin in a neonate with desminopathy

by Nga N., Bao B., Vy N., Cong N., Hiep N.

Summary: Whole-exome sequencing (WES), a high-throughput DNA sequencing method, has swiftly gained traction as a scalable approach for detecting novel de novo mutations and generating molecular diagnoses for genetic illnesses.


Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach

by Rehman S., Shafqat F., Usman M., Niaz K.

Summary: Triclosan (TCS) is present in toothpaste and other cosmetic products as an antibacterial and anti-fungal agent. This manuscript highlights that TCS is a potential oxidative stress-causing agent, an estrogenic, mutagenic, cancer-causing agent, and genotoxic agent present in cosmetic products. This study also summarizes the therapeutic approach to overcome all of the harmful effects. It is a popular current topic, and a new research study is needed to find a new alternative as an antibacterial and anti-fungal agent instead of TCS. TCS causes oxidative stress when the dynamic balance in synthesizing and removing reactive oxygen species (ROS) within typical physiological circumstances is disturbed. The antioxidant defence system includes both enzymatic and non-enzymatic antioxidants produced by the organism to tackle the harmful effects of ROS. TCSs have estrogenic, proliferative, and apoptotic properties due to research on cell fate. The mutagenic potential of TCS has been examined using in vitro and in vivo research in prokaryotic, eukaryotic systems, and mammalian cells. It also induces carcinogenic, estrogenic, and mutagenic effects. TCS's therapeutic effects, especially against inflammatory skin conditions, have been demonstrated by many materials gathered from in vitro and in vivo experiments. The new findings suggest that TCS, a commonly used cosmetic product, may cause cancer, as shown by animal and human models and clinical trials. TCS is not effectively regulated, as evidenced by its presence in various environmental media, human bodies, and animals. Its irresponsible usage and disposal may endanger humans and wildlife. TCS has been found to damage a wide variety of cells in cell-based investigations. TCS's exact function in the environmental selection of antibiotic and multidrug resistance genes is still unclear. Comprehensive evaluations of these domains, especially to derive serious human health risk inferences from TCS outcomes, may help future research and legislation to better serve the public's health.

Research articles

Comparison of Effect of Metformin Versus Combination of Folic Acid/Myo-inositol in Infertile Women with Poly Cystic Ovary Syndrome Undergoing In Vitro Fertilization: A Randomized Clinical Trial

by Rastegar F., Rezaee Z., Saedi N., Memari R., Tajpour M.

Summary: Previous studies have reported contradictory results regarding the effectiveness of metformin and myo-inositol on improving reproductive outcomes in patients with polycystic ovary syndrome (PCOS). Therefore, this study aimed to compare the effectiveness of these two drugs on improving reproductive outcomes of PCOS patients undergoing in vitro fertilization (IVF) treatment.

Research articles

Ameliorative Effect of Quercetin against Modification Induced by 5-Fluorouracil on Alpha-2-Macroglobulin

by Ali S., Ahsan H., Ansari S., Khan F.

Summary: Alpha-2-macroglobulin (α2M) is large glycoprotein, found in the plasma of vertebrates and invertebrates, which plays a major role in regulation and transport. In this study, we report the interaction of 5-fluorouracil (5-FU) with α2M and the protective effect of quercetin against 5-FU induced modification of α2M.


Complex diagnostics of early gastric cancer associated with Helicobacter pylori infection in the adult population of Siberia

by Olga S., Aleksandr S.

Summary: Most researchers point to a decrease in immunity indicators in patients with gastric cancer. At the same time, there are ambiguous interactions between tumor growth and the functioning of the immune system. Identifying gastric cancer patients at an early and curable stage of the disease is essential if the mortality rates for this disease are to decrease. The only way to prevent the development of gastric cancer is the potential reversibility of precancerous changes in the gastric mucosa. The early diagnosis of chronic atrophic gastritis is a preventive measure and it should be carried out in both the presence and absence of the symptoms of dyspepsia.


Breast cancer treatment by transplantations of dendritic cells and cytokine-induced killer cells: An update on clinical trials

by Ngo H., Pham P.

Summary: Breast cancer is the world's most common cancer in women and is the leading cause of their cancer-related mortality. Its early diagnosis with conventional therapies such as surgery, chemotherapy, and radiotherapy can give good results in most breast cancer patients. However, these therapies provide poor outcomes in metastatic breast cancers or late-stage breast cancer. Therefore, as another effort for breast cancer treatment, immunotherapy is now considered the fourth-line cancer treatment besides conventional therapies. In this article, we focus on breast cancer treatment by transplantation of cytokine-induced killer cells (CIKs) and dendritic cells (DCs). While CIKs are effector cells that can directly attack and kill breast cancer cells, DCs support other immune cells in including CIKs in antitumor activities. Although transplantation of CIKs or DCs alone gave limited results in breast cancer treatment, the combination of CIKs and DCs in current clinical trials demonstrated significant results. Thus, we propose that CIK-DC therapy will emerge as a new option for breast cancer treatment soon.

Research articles

Oxidative stress-mediated caspase-dependent intrinsic apoptosis and proautophagic therapeutic potential of Salvia moorcroftiana Wall. ex Benth. growing in the Kashmir Valley, India

by Khursheed A., Jain V.

Summary: Salviamoorcroftiana Wall. ex Benth. is a herbaceous perennial plant indigenous to the Himalayan mountains and especially common in the Kashmir Valley, India. This plant was selected based on its ethnopharmacological promise and the dearth of scientific reporting on its biological activity. This study examined the anticancer therapeutic potential of Salviamoorcroftiana Wall. ex Benth. and also sought to demonstrate its induction of apoptosis, autophagy, and oxidative stress in lung and breast cancer cells.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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Biomedical Research and Therapy seeks applications from enthusiastic researchers and scholars who can oversee and maintain the editorial direction of the journal to ensure a steady flow of engaging and thought-provoking original research publications.

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