journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

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Research articles

Ki-67 status in patients with primary breast cancer and its relationship with other prognostic factors

by Kermani T., Kermani I., Faham Z., Dolatkhah R.

Summary: Breast cancer (BC) is the most common cancer in women and is the second most common cause of fatality in patients with cancer in the world. Cell proliferation plays an important role in the clinical behavior of invasive BC. We aimed to assess the status of Ki-67 in patients with primary breast cancer and evaluate the association of this tumor marker with other clinico-pathologic and prognostic factors.


A proposition for a cancer treatment study using radioactive metal co-factor enzymes

by Tran L.

Summary: Cancer is a serious pathological condition of abnormal cells are gathered in tumors in the body's tissues or organs. Due to their accelerated metabolism, cancer cells require a great demand for energy, protein (cell structure substrates), and metabolic enzyme activity. If the body does not respond adequately to this demand, the metabolic processes of cancer cells will be hampered, and their growth will be limited or even stopped. It is possible to control the metabolic processes of the cancerous tumors by performing one or more of the following approaches: stopping the energy and cell structure substrate supply, inhibiting enzymic activity, and/or destroying cancer cells with external agents (such as radiation and/or chemicals). These approaches have been investigated either in single or combination modes, but so far the results obtained have not been on par with expectations. In this paper, we propose a method of cancer treatment which entails the use of a radioisotope instead of stable metal to break down the structure of metal co-factor enzyme and to deactivate its catalytic function. With a judicious choice of the metal radioisotope, this method is even able to perform all the above-mentioned approaches, and at the same time, giving a much better efficacy in cancer treatment.

Research articles

Effect of Thalidomide on Cox-2 expression in bleomycin-induced pulmonary fibrosis in mice

by Rezaie M., Rostamzadeh A., Keshavarz G., Amraei M., Moayeri A.

Summary: Lung fibrosis is a progressive, fatal disease that is characterized by increasing fibroblasts proliferation and extracellular matrix precipitation. Studies have shown that cyclooxygenase- 2 (Cox-2) could play a crucial role in the pathogenesis of lung fibrosis. In the current study, the effect of thalidomide on bleomycin-induced pulmonary fibrosis was qualitatively studied in a laboratory animal model.

Case report

Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

by Payandeh M., Karami A., Karami N., Enayati S., Aeinfar M.

Summary: Leukemia cutis (LC) is a rare disorder that is distinguished by the infiltration of leukemic cells into the skin. This can be a manifestation of relapse of the previously treated leukemia. We report a case of a 70-year-old woman with acute monocytic leukemia (AMOL), whose disease relapsed and developed into LC after a successful induction therapy. Salvage chemotherapy has been applied successfully to prevent the development of LC in the patient's skin.

Case report

A type 2 diabetes mellitus patient was successfully treated by autologous bone marrow-derived stem cell transplantation: A case report

by Le P., Doan N., Tien P., Hoang D., Phan N., Pham P.

Summary: Type 2 diabetes mellitus (T2DM) iscurrently one of the most common diseases as a result of obesity and aging. Currently, T2DMis treated by various methods, such as insulin injection and glucose regulation agents. In this report, we report the case of a T2DM patient who was successfully treated by autologous bone marrow-derived stem cell transplantation.

Research articles

Efficacy of topical cinnamon gel for the treatment of facial acne vulgaris: A preliminary study

by Ghovvati M., Afshari G., K., Nasrollahi S., A., Firooz A., Samadi A., Karimi M., Talebi Z., Kolahdooz S., Vazirian M.

Summary: Acne vulgaris is a common chronic disorder of the pilosebaceous unit. Topical therapy is the mainstay of treatment for mild-to-moderate acne. Two main problems with conventional anti-acne treatments are antibiotic resistance and local side effects. In this regard, medicinal herbs could be an alternative choice for developing new products with fewer side effects. Objective: The purpose of this study was to evaluate the safety and efficacy of a topical formulation of cinnamon in patients with facial acne.

Research articles

Effects of porcine granulocyte-macrophage-colony-stimulating factor on porcine cumulus-oocyte complex maturation in vitro

by Dang L., Le T.,-T., Huynh C., Hoang S.

Summary: The in vitro maturation (IVM) of oocytes is an essential step in the in vitro embryo production. This study aimed to improve the efficacy of IVM by supplementing with granulocytemacrophage colony stimulating factor (GM-CSF) in the culture medium.


The use of nootropics in Alzheimer’s disease: is there light at the end of the tunnel?

by Chiroma S., M., Taib C., N., M., Moklas M., A., M., Baharuldin M., T., H., Amom Z., Jagadeesan S.

Summary: The nootropic or simply known as smart drug is a common term given to any compound that is responsible for enhancing mental capability or performance. Alzheimer's disease is characterized clinically by lose of cognitive abilities and pathologically by two hallmark lesions, neurofibrillary tangles and senile plaques. It is unfortunate that AD has no cure yet. In this review attempt has been made to elucidate the general views on AD pathogenic hypotheses and common nootropics being used in AD research.

Research articles

Risk factors of peripheral neuropathy in patients with type 2 diabetes in Isfahan: Results of a cohort study in Iran

by Mohammadian-Hafshejani A., Majdzadeh R., Mansournia N., Mansournia M. A.

Summary: Peripheral neuropathy (PN) is among the most prevalent complications of diabetes that can lead to impairment of mobility of diabetic patients. The purpose of the current study was to predict relative factors influencing the occurrence of peripheral neuropathy (PN) in patients with type 2 diabetes.

Research articles

Revisiting Prostate Biopsy with 2014 ISUP Modified Gleason Score and Gleason Grade – A Cross Section Study

by Shah M., B Raju K., Kumar G H.

Summary: Prostatic carcinoma is one of the most common carcinomas among men throughout the world. Gleason score (GS) system is used in reporting and assessing the prognosis of prostatic carcinoma. The GS has undergone modifications. The objective of this study is to evaluate the impact of the new 2014 ISUP Modified Gleason System and Gleason grading (GG) on reporting of prostatic carcinoma.

Research articles

Comparison of clinical outcome of frozen embryo transfer after embryo selection based on morphokinetic versus morphologic criteria for freezing

by Quang L., N., Tram L., T., B., Thuy N., H., M., Toan P., D., Vinh D., Q., Huyen N. T. T.

Summary: Results from the latest meta-analysis, in fresh cycles, showed that the application of time-lapse monitoring (TLM) together with an embryo-evaluating algorithm was associated with a significantly higher rate of ongoing pregnancy and a lower rate of early pregnancy loss. The aim of this study was to compare the clinical outcomes of frozen embryos classified according to morphokinetic versus morphologic criteria.


The role of brain natriuretic peptides as a marker for diagnosing cardiac syncope: A narrative review

by Disfani H., F., Kamandi M., Rahmani K.

Summary: Cardiac disease is the second common cause of syncope in emergency departments. Patients with Cardiac syncope have a higher risk of mortality than those who have a non-cardiac problem. Brain natriuretic peptide (BNP) as a cardiac marker has not thoroughly been evaluated in patients with syncope. This article focuses on the studies that have assessed BNP and NT-pro-BNP in cardiac and non-cardiac syncope patients in emergency departments.

Research articles

Effects of prophylactic ketamine and pethidine to control postanesthetic shivering: A comparative study

by Khoshfetrat M., Jalali A., R., Komeili G., Keykha A.

Summary: Shivering is an undesirable complication following general anesthesia and spinal anesthesia, whose early control can reduce postoperative metabolic and respiratory complications. Therefore, this study aims to compare the effects of prophylactic injection of ketamine and pethidine on postoperative shivering.

Research articles

Cyclosporine-A induced nephrotoxicity in male and female rats: Is zinc a suitable protective supplement?

by Choopani S., Kasaei S., Talebi A., Mortazavi M., Gheisari Y., Matinfar M., Nematbakhsh M.

Summary: Cyclosporine (CYC) is an immunosuppressant drug used widely in kidney transplant patient. The major side effect of CYC is nephrotoxicity. In this study, three different doses of CYC alone or accompanied with zinc (Zn) supplement were administrated in male and female rats to determine the kidney tissue damages and functions.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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