journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. 

Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics.

Biomedical Research and Therapy is indexed and abstracted in major databases included Web of Science (ESCI - Emerging Sources Citation Index, Clarivate Analytics), Scopus (Elsevier), Embase, ...

The journal is published monthly, 12 issues per year.

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Research articles

Effects of aqueous extract of polyherbal formulation against hyperthyroidism induced by L-thyroxin in a rat model

by Ahmed S., B. Moghazy A., M. Ahmed-Farid O., A. Esebery H. A.

Summary: Hyperthyroidism is a disorder that occurs when the thyroid gland secretes more thyroid hormone than the body needs. Thyroid hormone is essential for the normal growth and development of normal organs. Polyherb (POH) formulation has proven to be useful in number of diseases and has been used in folk medicine as an anti-hyperthyroidism, anti-oxidant, and appetitestimulating agent. The aim of the study was to evaluate the curative effect of POH against L-thyroxin (LT4)-induced hyperthyroidism in male rats.

Research articles

Elevated levels of circulating soluble ST2 at discharge predict late adverse ventricular remodeling in patients with ST-segment elevation myocardial infarction

by Petyunina O., V. Kopytsya M., P. Berezin A. E.

Summary: The aim of this study was to investigate whether the circulating level of sST2 would predict adverse LV remodeling in STEMI patients with TIMI III flow through the myocardial infarctrelated coronary artery six months after intervention.

Research articles

Clinical, microbiological research of the effectiveness of inhalation use of quaternary ammonium antiseptic in the prevention and treatment of infectious respiratory complications in critically ill patients

by Nazarchuk O., A. Dmytriiev D., V. Dmytriiev K. D.

Summary: The aim is to study the microbiological and clinical efficacy of decamethoxinebased quaternary ammonium antiseptic inhalations in the complex management of respiratory infectious complications in critically ill children.

Research articles

Development and evaluation of 12-lead electrocardiogram in the left free wall of accessory pathway localization in patients with typical Wolff-Parkinson-White syndrome

by Chu S., Pham K., Tran D.

Summary: This study was designed to characterize 12-lead electrocardiogram (ECG) for localization of the left free wall lateral accessory pathway (AP) in patients with typical Wolff-Parkinson-White (WPW) syndrome, to develop a new algorithm ECG for localizing APs, and to test the accuracy of the algorithm prospectively.

Research articles

Anodal transcranial direct current stimulation enhances positive changes in movement functions, visual attention and depression of patients with chronic ischemic stroke: A clinical trial

by Hosseinzadeh S., A., Mazhari S., Najafi K., Ahmadi M., Aghaei I., Khaksarian M.

Summary: Stroke is one of the most serious and debilitating diseases in our society. Stroke survivors can suffer several neurological impairments. They typically show pathological changes in neural functions of brain areas. Transcranial direct current stimulation (tDCS) can be applied to modify cerebral excitability and has been recently applied in the treatment of neuropsychological and neurological disorders. The aim of the study herein was to evaluate changes in movement and cognitive functions of chronic ischemic stroke patients using anodic and cathodic tDCS.

Research articles

Investigating cell blood counter and abdominal radiography accuracy in diagnosis of acute suppurative appendicitis among patients under surgery

by Shahmoradi M., K., Mahmoudvand H., Nadri S., Niazi M., Adeli M., Rouientan A.

Summary: Acute appendicitis is the most common surgical emergencies; while unusual symptoms have a differential diagnosis. This study aimed to determine the diagnostic accuracy of CBC and abdominal X-ray in acute suppurative appendicitis.


Renal cell carcinoma: a systematic review and meta-analysis on expression of androgen receptor

by Abdi H., Reza Mozaffari H., Payandeh M., Sadeghi E.

Summary: Chromosome Xq11-12 is the place that the androgen receptor (AR) sequence appears. Herein, the prevalence of this biomarker and its relation with pT stage and tumor grade was reported.

Research articles

Evaluation of the efficacy of a topical chamomile-pumpkin oleogel for the treatment of plaque psoriasis: an intra-patient, double-blind, randomized clinical trial

by Kolahdooz S., Karimi M., Esmaili N., Zargaran A., Kordafshari G., Mozafari N., Ayati M.. H.

Summary: Plaque psoriasis is a chronic inflammatory skin disease. Conventional treatments of psoriasis are not completely effective. In addition, unwanted side effects limit their long-term use. In this regard, developing new natural treatments with fewer side effects could be an alternative option. This study was designed to evaluate the efficacy and safety of topical chamomile-pumpkin oleogel (ChP) in treating plaque psoriasis.

Research articles

Mesenchymal stem cells accelerate liver regeneration in acute liver failure animal model

by Putra A., Antari A., D., Kustiyah A., R., Intan Y., S., N., Sadyah N., A., C. Wirawan N., Astarina S., Zubir N., Munir D.

Summary: The massive hepatic necrosis of acute liver failure (ALF) results in a sudden loss of hepatic cells. Although most hepatocyte cells of ALF are completely lost, stem cell-derived circulating cells and endogenous progenitor cells rapidly regenerate them. Mesenchymal stem cells (MSCs) have a critical role in the regeneration of liver injury through regulating platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) levels. However, their fluctuating levels in the healing process and correlation to the decrease of liver function markers remain unclear. The aim of this study was to analyze the effects of MSCs in accelerating liver regeneration of ALF by measuring VEGF and PDGF levels on day 2 and 7, as well as SGPT and SGOT levels, and assessing histopathology appearance.

Case report

Non-syndromic multiple impacted teeth: two case reports

by Delavarian M., Delavarian F., Imani M. M.

Summary: Multiple impacted permanent teeth is a rare finding and often associated with systemic diseases or some rare syndromes. This article reports two Iranian cases with multiple impacted teeth without systemic disease or syndromes. The first patient, a 17-year-old male, had 18 unerupted teeth and 9 unerupted supernumerary teeth. The second patient, a 16-year-old female, had 14 unerupted teeth. In these cases, an interdisciplinary approach between orthodontist, oral surgeon and prosthodontist is required to achieve optimum facial aesthetics and functional occlusion.


Correction to: Insertion / Deletion Polymorphism of Angiotensin Converting Enzyme Gene Does Not Contribute to Chronic Kidney Disease in Palestine

by Abuaisha A., M., Marzoq L., F., A., Eljbour M., S., Fayyad E., S., Baraka A., K., Serakinci N.


Research articles

Survival analysis of liver cirrhosis patients after transplantation using accelerated failure time models

by Abolghasemi J., Toosi M., Rasouli M., Taslimi H.

Summary: Liver transplantation is known as the only treatment for advanced liver cirrhosis. Considering the importance of identifying the factors affecting the survival of cirrhosis patients after transplantation in order to improve the health of these patients and increase their longevity, this study was conducted to fit the best accelerated failure time model for survival analysis of cirrhosis patients.

Research articles

Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease and its correlation with disease severity

by Moayyedkazemi A., Rahimirad M. H.

Summary: It has been proven that patients with chronic obstructive pulmonary disease (COPD) are at risk for increased atherothrombotic events. Studies have demonstrated that C-reactive protein (CRP) and COPD are risk factors for heart disease. The present study aimed to evaluate the serum level of CRP in patients with COPD and compare it with those of the control group.

Research articles

Efficacy of adding Luvos® Healing Earth supplementation to mebeverine in improving symptoms and quality of life of patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial

by Mokhtare M., Asadipanah M., Bahardoust M., Chaharmahali A., Sikaroudi M., Khoshdelnezamiha M., Davanloo F., Masoodi M., Bahadorizadeh L.

Summary: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Treatment can improve symptoms and social functioning in the patients. This study was designed to assess the effect of adding Luvos supplementation to mebeverine on improving symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable bowel syndrome.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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