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Evaluation effects of ascorbic acid leads to activate and induce osteogenic protein marker expression: in silico and in-vitro study
by Rosadi
I.,
Indrady
F., T.,
Karina
K.,
Hariani
N.
Summary: Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into several cell types including chondrocytes and osteocytes. The process of differentiation into such tissues is aided by transcription factors and collagen gene markers. Collagen biosynthesis is influenced by the presence of vascular endothelial growth factor (VEGF) and ascorbic acid cofactors of the prolyl hydroxylase 2 (PHD2) enzyme found in human cell receptors. The focus of this study is evaluation of how in silico methods can elucidate the effect of ascorbic acid on PHD2 and its expression. This study aimed to evaluate the role of ascorbic acid in its interaction with PHD2 (in silico) and the expression of type 1 collagen (COL1), type 2 collagen (COL2), and VEGF.
Long QT syndrome: Identification of a novel de novo mutation of calmodulin in a newborn girl
by Nguyen
T., H., N.,
Bui
C., B.,
Nguyen
V., T., V.,
Nguyen
M., C.,
Vu
N., T., T.,
Nguyen
M. H.
Summary: Long QT syndrome (LQTS) is a genetically and phenotypically heterogeneous disorder of ventricular myocardial repolarization that is typically characterized by prolongation of the heart rate-corrected QT interval on a 12-lead electrocardiogram (ECG). LQTS has a complicated etiology since great genotypic and phenotypic overlapping among LQTSs limits the establishment of a diagnosis based solely on clinical features.
Mature Placental Teratoma: A Case Report
by Khormoji
N.,
Soleimani
V.,
Sheikhhasani
S.
Summary: Placental teratoma is an uncommon, non-trophoblastic benign tumor. Since the first description of this type of tumor by Morvilli in 1925, only a few cases of this abnormality have been diagnosed and reported.
A Rare Case of Pseudoaneurysm and an Arteriovenous Fistula of the Lumbar Artery Treated by Endovascular Intervention
by Dung
L.,
Duc
N.,
My
T.,-T.,
Luu
D.,
Linh
L.,
Chau
T.
Summary: Traumatic lumbar artery injuries are quite uncommon, and arteriovenous fistula (AVF) lesions are also rare. The clinical symptoms associated with AVF of the lumbar artery are often vague and non-specific and can be masked by symptoms due to the spinal cord injury. Therefore, AVF of the lumbar artery can often be missed if the performance of a contrast-enhanced computed tomography (CECT) scan is absent. In this article, we portrait a case of post-traumatic lumbar artery AVF along with pseudoaneurysm in a 40-year-old who suffered from pain in the right lumbar region. After endovascular intervention therapy for one month, the Visual Analogue Scale (VAS) was 1 in comparison with 8 prior to treatment. Thus, an endovascular intervention should be considered an effective treatment option for AVF and pseudoaneurysm of the LA.
Generation of Bacillus subtilis displaying alpha-toxin HlaH35LH48L fused with CotB and CotG, and studying the immune response in mice
by Nguyen
N.,
Duong
L.,
Truong
D.,
Nguyen
T.,
Nguyen
A.,
Nguyen
T.,
Nguyen
U.,
Dinh
T.,
Thanh
D.,
Nguyen
H.
Summary: The Bacillus subtilis spore is considered to be a powerful vehicle for surface display and antigen delivery. Being safe and widely used for the purpose of oral bacteriotherapy in humans and animals, B. subtilis spore has potential in the domain of needle-free vaccine development. The spores themselves also behave as an adjuvant. This study aims to generate B. subtilis spores expressing mutant staphylococcal alpha-toxin HlaH35LH48L on the surface and to study their ability to evoke a specific immune response in mice.
Diabetic dyslipidemia: A screening tool for cardiovascular risk assessment
by Ali
S.,
Rao
N.,
Amir
S.
Summary: Dyslipidemia is the most common threat in connection to developing cardiac disorders in type two diabetes mellitus. It has a role in the eventual development of atherosclerosis and increased mortality and morbidity. The present study was conducted to determine the lipoprotein abnormalities found in type two diabetic patients in the Mangalore region in South India.
Elevated expression of SKP2 correlates with poor prognosis in osteosarcoma: a bioinformatics analysis
by Hoang
T.,-M.,
Nguyen
M.,-T.,
Chen
W.,
Zhuang
C.,
Wang
Z.,
Wang
H.,
Li
J.,
Lin
H.
Summary: Osteosarcoma (OS) is the most prevalent kind of bone cancer, but the tumorigenesis and underlying molecular drivers of OS remain unknown. The instability of the cell cycle regulation system, which leads to uncontrolled cell proliferation, is a typical characteristic of carcinogenesis. This study aimed to investigate the expression of SKP2 in human OS and assessed its prognostic value in OS patients.
Identification of a novel de novo deletion mutation of desmin in a neonate with desminopathy
by Nga
N.,
Bao
B.,
Vy
N.,
Cong
N.,
Hiep
N.
Summary: Whole-exome sequencing (WES), a high-throughput DNA sequencing method, has swiftly gained traction as a scalable approach for detecting novel de novo mutations and generating molecular diagnoses for genetic illnesses.
Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach
by Rehman
S.,
Shafqat
F.,
Usman
M.,
Niaz
K.
Summary: Triclosan (TCS) is present in toothpaste and other cosmetic products as an antibacterial and anti-fungal agent. This manuscript highlights that TCS is a potential oxidative stress-causing agent, an estrogenic, mutagenic, cancer-causing agent, and genotoxic agent present in cosmetic products. This study also summarizes the therapeutic approach to overcome all of the harmful effects. It is a popular current topic, and a new research study is needed to find a new alternative as an antibacterial and anti-fungal agent instead of TCS. TCS causes oxidative stress when the dynamic balance in synthesizing and removing reactive oxygen species (ROS) within typical physiological circumstances is disturbed. The antioxidant defence system includes both enzymatic and non-enzymatic antioxidants produced by the organism to tackle the harmful effects of ROS. TCSs have estrogenic, proliferative, and apoptotic properties due to research on cell fate. The mutagenic potential of TCS has been examined using in vitro and in vivo research in prokaryotic, eukaryotic systems, and mammalian cells. It also induces carcinogenic, estrogenic, and mutagenic effects. TCS's therapeutic effects, especially against inflammatory skin conditions, have been demonstrated by many materials gathered from in vitro and in vivo experiments. The new findings suggest that TCS, a commonly used cosmetic product, may cause cancer, as shown by animal and human models and clinical trials. TCS is not effectively regulated, as evidenced by its presence in various environmental media, human bodies, and animals. Its irresponsible usage and disposal may endanger humans and wildlife. TCS has been found to damage a wide variety of cells in cell-based investigations. TCS's exact function in the environmental selection of antibiotic and multidrug resistance genes is still unclear. Comprehensive evaluations of these domains, especially to derive serious human health risk inferences from TCS outcomes, may help future research and legislation to better serve the public's health.
Comparison of Effect of Metformin Versus Combination of Folic Acid/Myo-inositol in Infertile Women with Poly Cystic Ovary Syndrome Undergoing In Vitro Fertilization: A Randomized Clinical Trial
by Rastegar
F.,
Rezaee
Z.,
Saedi
N.,
Memari
R.,
Tajpour
M.
Summary: Previous studies have reported contradictory results regarding the effectiveness of metformin and myo-inositol on improving reproductive outcomes in patients with polycystic ovary syndrome (PCOS). Therefore, this study aimed to compare the effectiveness of these two drugs on improving reproductive outcomes of PCOS patients undergoing in vitro fertilization (IVF) treatment.
Ameliorative Effect of Quercetin against Modification Induced by 5-Fluorouracil on Alpha-2-Macroglobulin
by Ali
S.,
Ahsan
H.,
Ansari
S.,
Khan
F.
Summary: Alpha-2-macroglobulin (α2M) is large glycoprotein, found in the plasma of vertebrates and invertebrates, which plays a major role in regulation and transport. In this study, we report the interaction of 5-fluorouracil (5-FU) with α2M and the protective effect of quercetin against 5-FU induced modification of α2M.
Complex diagnostics of early gastric cancer associated with Helicobacter pylori infection in the adult population of Siberia
by Olga
S.,
Aleksandr
S.
Summary: Most researchers point to a decrease in immunity indicators in patients with gastric cancer. At the same time, there are ambiguous interactions between tumor growth and the functioning of the immune system. Identifying gastric cancer patients at an early and curable stage of the disease is essential if the mortality rates for this disease are to decrease. The only way to prevent the development of gastric cancer is the potential reversibility of precancerous changes in the gastric mucosa. The early diagnosis of chronic atrophic gastritis is a preventive measure and it should be carried out in both the presence and absence of the symptoms of dyspepsia.
Breast cancer treatment by transplantations of dendritic cells and cytokine-induced killer cells: An update on clinical trials
by Ngo
H.,
Pham
P.
Summary: Breast cancer is the world's most common cancer in women and is the leading cause of their cancer-related mortality. Its early diagnosis with conventional therapies such as surgery, chemotherapy, and radiotherapy can give good results in most breast cancer patients. However, these therapies provide poor outcomes in metastatic breast cancers or late-stage breast cancer. Therefore, as another effort for breast cancer treatment, immunotherapy is now considered the fourth-line cancer treatment besides conventional therapies. In this article, we focus on breast cancer treatment by transplantation of cytokine-induced killer cells (CIKs) and dendritic cells (DCs). While CIKs are effector cells that can directly attack and kill breast cancer cells, DCs support other immune cells in including CIKs in antitumor activities. Although transplantation of CIKs or DCs alone gave limited results in breast cancer treatment, the combination of CIKs and DCs in current clinical trials demonstrated significant results. Thus, we propose that CIK-DC therapy will emerge as a new option for breast cancer treatment soon.
Oxidative stress-mediated caspase-dependent intrinsic apoptosis and proautophagic therapeutic potential of Salvia moorcroftiana Wall. ex Benth. growing in the Kashmir Valley, India
by Khursheed
A.,
Jain
V.
Summary: Salviamoorcroftiana Wall. ex Benth. is a herbaceous perennial plant indigenous to the Himalayan mountains and especially common in the Kashmir Valley, India. This plant was selected based on its ethnopharmacological promise and the dearth of scientific reporting on its biological activity. This study examined the anticancer therapeutic potential of Salviamoorcroftiana Wall. ex Benth. and also sought to demonstrate its induction of apoptosis, autophagy, and oxidative stress in lung and breast cancer cells.
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Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Embase (Elsevier), Google Scholar
Annual Journal Metrics
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Speed
26 days to first decision for all manuscripts
37 days from submission to acceptance
12 days from acceptance to publicationJournal Citation Indicator (JCI)
0.16 - Journal Citation IndicatorJournal Impact Factor (JIF)
Not yetAcceptance Rate
54.32%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
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Editor-in-Chief: pvphuc@bmrat.org; pvphuc@hcmus.edu.vn; phucpham@sci.edu.vn, pvphuc@vnuhcm.edu.vn
Support Team: support@bmrat.org; contact@bmrat.org
Managing Editor: managingeditor@bmrat.org
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