Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease and its correlation with disease severity
Serum hsCRP is higher in the COPD group than the control group matched based on age, and hsCRP is correlated with the severity of COPD. Further studies with larger sample sizes are required for evaluating this correlation in patients with COPD....
Mesenchymal stem cells accelerate liver regeneration in acute liver failure animal model
The study showed an significant (P<0.001) increase of PDGF and VEGF levels on the 2nd day, followed by a decrease on the 7th day, along with a decrease of SGPT and SGOT levels as well as the normality of histology appearance.....
Mesenchymal stem cells for diabetes mellitus treatment: new advances
MSC transplantation in preclinical trials and clinical trials for T1DM and T2DM have shown a moderate to significant improvement in diabetes without adverse side effects. In this review, we will discuss some of the updates from preclinical and clinical trials of MSC transplantation for diabetes....
Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma
Summary: Plant-mediated synthesis of silver nanoparticles (AgNPs) is accounted as an ecofriendly process. The present study was conducted to estimate the potency of biogenic AgNPs against Ehrlich ascites carcinoma (EAC) cells in vitro and EAC-bearing mice in vivo.
Probiotics: Helpful for the prevention of COVID-19?
Summary: Up to now, no vaccine has been developed for COVID-19 treatment. Although many scientists are working for the rapid development of a vaccine to control this pandemic, nonetheless, it will take time. If the vaccine will be developed soon, it will not be available to the entire world instantly since the mass production of the vaccine will take time. In this scenario, we will have to take alternative measures to control the COVID-19 pandemic. These alternative approaches include the stimulation of the immune system to fight against viral infections. Among the different approaches to strengthen the immune system, the use of probiotics is the best one. Probiotics can help the body to fight against COVID-19 directly and indirectly. In this review, we comprehensively discuss the use of probiotics for the prevention and control of COVID-19.
Clinical decision-making approaches by health caregivers of patients with COVID-19
Summary: The Coronavirus disease of 2019 COVID-19) is the current health crisis in the world- a new, complex phenomenon that has affected and hospitalized many people around the world. Health care providers deal with COVID-19 patients daily and care for the patients while there is no definitive cure for it. Clinical decision-making is an important task of health professionals that plays an essential role in preserving the patient's life and providing quality care. Therefore, understanding clinical decision-making approaches by healthcare providers, such as nurses and physicians, especially in crises such as COVID-19, is essential.
Kidney damage by COVID-19 and rationale for extracorporeal therapies
Summary: Without doubt, there is some involvement of the kidney in novel coronavirus disease (COVID-19), which is responsible for multiple organ dysfunctions resulting in severe complications in the human body. This newly discovered COVID-19 has incited panic globally. However, the role of kidney involvement in the novel COVID-19 disease is still unclear. In this commentary, we discuss the various pathways involved in kidney damage by COVID-19, and the rationale for extracorporeal support with various blood purification strategies in critically ill people with COVID 19.
Primary primitive neuroectodermal tumor of the orbit in an adult: Case report and literature review
Summary: Primitive neuroectodermal tumors (PNETs) are malignant soft tissue tumors of neuroepithelial origin with an aggressive nature and associated with early disseminated metastasis, resulting in poor prognosis. It occurs more frequently in men of age < 35 years, and in several parts of the body, such as pulmonary tract, nasal cavity, paranasal sinuses, and/or neck. Orbital location is infrequent and has been reported in less than 20 cases in the English literature so far.
Epiploic appendagitis diagnosis linked to intestinal symptoms: Case reports
Summary: Epiploic appendices are small pouches filled with projection-like fat structure adjacent to the antimesenteric side of the colon wall; they range in size from 0.5 to 5 cm and provide vascularization from small arterioles. Epiploic appendagitis is a benign condition of the epiploic appendices which leads to ischemia of the structure. Ischemia, therefore, causes localized sharp abdominal pain. Though uncommon, its symptoms can be diagnosed as acute lower abdominal pain since the symptoms could mimic diverticulitis and appendicitis. Thus, to diagnose epiploic appendagitis in this case, a CT scan was conducted to detect a fat-dense lesion of ovoid-like structure close to the colon. Given the good response to conservative management, establishing a correct diagnosis could help to minimize inappropriate invasive management.
Toxicity effects of Cubic Cu2O nanoparticles on defecation rate and length in C. Elegans
Summary: The increased presence of radiation and toxins in the atmosphere has given rise to fuel cells and nanoparticle technology with the ability to catalyze reactions at favorable energy levels. The purpose of this experiment was to determine the lasting effects of a synthesized catalyst on a model organism, Caenorhabditis (C.) elegans.
Characterization of synovium-derived mesenchymal stem cells from joints with osteochondritis dissecans
Summary: Osteochondritis dissecans (OCD) is a pathologic condition that occurs in children as well as adults. OCD is often managed based on the extent of ischemia and the stage of the disease. Synovial tissue collected during an arthroscopic procedure might serve as an ideal source for autologous mesenchymal stem cells (MSCs) with a potential for regenerative medicine of cartilage. Therefore, the present in vitro study aimed to evaluate the potency characteristics of synovium-derived MSCs (SMSCs) from joints with OCD for prospective autologous therapy.
Relapses of desquamative glossitis in patients with gastroesophageal reflux disease
Summary: This article addresses the issues of pathological manifestations on the tongue of patients with gastroesophageal reflux disease (GERD), as well as the duration of the remission period after treatment. It was revealed that the patients with GERD who received treatment for desquamative glossitis noted a significant decrease in the intensity of subjective and objective manifestations immediately after treatment. However, in cases where no repeated courses of treatment were undertaken, an unstable remission was observed in the oral cavity and new desquamation foci appeared on the tongue. As an example, the article describes the clinical case of a patient with GERD manifestations in the oral cavity who received treatment for desquamative glossitis in 2011.
Antibacterial cellulose-based aerogels for wound healing application: A review
Summary: Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.
Microcirculatory effects of systemic metabolic correction with reactive oxygen species: An experimental study
Summary: The purpose of this study is to estimate microcirculation changes under systemic (intraperitoneal) administration of ozonized saline.
Convalescent plasma successfully treats a severe COVID-19 patient with multi-organ failure
Summary: Due to the high mortality rate of coronavirus disease 2019 (COVID-19) and the lack of specific treatment for the disease, it is essential to find new therapies. The present case report aimed to assess the efficiency of convalescent plasma in patients with severe acute respiratory syndrome coronavirus 2. We reported a severe case of COVID-19 with multi-organ failure, who had reduced oxygen saturation after several courses of antiviral therapy. Moreover, computed tomography (CT) scan results showed patchy lesions in the base of lungs. Therapeutic measures, including endotracheal intubation and plasmapheresis with convalescent plasma, were performed for the patient; subsequently, good responses to the treatments were observed. Our findings demonstrate that convalescent plasma improves pulmonary lesions and the patient's clinical status.
Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry
Summary: Cumin (Cuminum cyminum L.) is an annual plant that is not only one of the most popular seed species but also one of the oldest and most cultivated aromatic and herbaceous natural products with numerous medicinal, nutraceutical, and pharmaceutical properties. It is widely used in the beverage, food, liquor, medicine, perfume, and toiletry industries. The objective of this work was to provide a precise and up-to-date review of the ethnopharmacology, phytochemistry, and biological activities of cumin.
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