journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

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Research articles

The effects of the Panax Vietnamensis ethanol fraction on proliferation and differentiation of mouse neural stem cells

by Do H., Q., Truong N., H., Lam T., T., Nguyen L., T., Le D., M., Dinh N., H.,-T., Tran L., C., Le P., T.,-B., Phan N., K., Pham P. V.

Summary: Panax vietnamensis Ha et Grushv. (Ngoc Linh ginseng) – a new species recently discovered in Vietnam – has received much interest due to its rich content of saponins, including those unknown. This study assessed the effects of the Ngoc Linh ginseng extract fractions on proliferation and differentiation of cultured mouse neural stem cells.

Research articles

Comparable effect of adipose-derived stromal vascular fraction and mesenchymal stem cells for wound healing: An in vivo study

by Karina K., Rosadi I., Sobariah S., Afini I., Widyastuti T., Rosliana I.

Summary: Mesenchymal stem cells (MSCs) have been known to have angiogenic potency, particularly for wound healing. However, it is such a cumbersome procedure to obtain a large amount of MSCs due to the culture process. The stromal vascular fraction (SVF), or so called nonexpanded MSCs, of adipose tissue is gaining increased interest in the field of cell therapy. An optimized method that takes only 2 hours to produce a large amount of stromal cells from adipose tissue has been developed. Burn wound model was used to assess the efficacy of SVF produced by our method. This study aimed to evaluate the efficacy of SVF compared to MSCs.

Research articles

Assessment of clinical judgment accuracy provided by emergency physicians in comparison with Peak Flowmetry in the severity and discharge criteria of patients with asthma attack

by Davood Sharifi M., Feiz Disfani H., Reza Rahmatzadeh H.

Summary: In the emergency department, the decisions on admission or discharge are based on clinical symptoms and physical examinations. The aim of this study is to compare the assessment of emergency physician clinical judgment accuracy with the actual amount of peak expiratory flow rate (PEFR).


Deciphering the role of AMPK-related kinase 5 in human cancer progression and metastasis

by Bambang A., Tanadi C., Sumarpo A.

Summary: Malignancies related mortality is currently growing at an alarming rate. Early detection of cancer is vital in order to improve survival rates of cancer patients, and biomarker detection is regarded as one of the most promising approaches. Recent studies have reported that elevated AMPK-related kinase 5 (ARK5) expression is associated with tumor progression and metastasis in several human malignancies. Several pathways are also influenced by the presence of ARK5, most notably the PI3k-Akt pathway, m-TOR phosphorylation, and several pathways that induce increased tumor invasion activity. Additionally, ARK5 expression are linked to miR-1181 down-regulation, which promotes epithelial mesenchymal transformation in ovarian cancer cells. Furthermore, ARK5 gene transcription is also affected by the interaction of c-MAF and MAFB with both MARE core sequences present in the ARK5 promoter. Based on the current evidences, ARK5 might be the master regulator of cancer progression and metastasis, which could potentially serve as a novel target for cancer therapies.

Research articles

Comparison of sublingual versus vaginal misoprostol in the management of missed abortions

by Rabiei S., Khansari S., Fallah M., Ajand M.

Summary: Missed abortion is one type of abortions in which the product of a pregnancy is dead and does not leave the cervix, despite a long period of time. Missed abortion requires urgent action due to serious maternal complications. The purpose of this study was to investigate and compare the effects of using misoprostol on the treatment of missed abortions by two different methods.

Research articles

Physiological and behavioral study on depressed rats model treated with Hordeum vulgare extract referenced to SSRI class

by Elbakry K., A. E., Alazabi N., Omer N., Bahnasawy M., Ahmed-Farid O.

Summary: The aim of the present study is to investigate the effects of Hordeum vulgare aqueous extract (HVE) in a sub-chronic depression rat model.

Research articles

Toxicological evaluation of the nicotine on CA1 and protective effects of curcuma longa: An experimental study

by Salahshoor M., R., Roshankhah S., Roudsari B., A., Jalili C.

Summary: Nicotine is the most important alkaloid compound in tobacco and is a major risk factor in the development of functional disorders of several organ systems. Some plants produce Curcuma longa (curcumin), which has antioxidant and neuro-protective properties.

Research articles

Evaluation of body weight, serum glucose level and oxidative stress parameters of diabetic rats administered phenolic aqueous leaf extract of Vitex doniana

by Obasi E., Iheanacho K., Nwachukwu N., Agha N., Chikezie P. C.

Summary: The present study evaluated the effect of phenolic aqueous leaf extract of Vitex doniana on body weight, serum glucose and oxidative stress parameters in diabetes mellitus (DM) rats.

Research articles

The effect of Phaseolus vulgaris pods extract on cytokines profile in the condition of alkali burn esophagus 2 degree

by Raetska Y., Dmytryk V., Chornenka N., Halenova T., Raksha N., Vovk T., Savchuk O., Ostapchenko L.

Summary: As a result of alkaline substances entering the esophagus wall, necrosis occurs, as well as destruction of the mucous, submucosal and muscular layers of the esophagus. The cellular immune system plays an important role in regulating the various phases of the wound healing process, during which, depending on the time and through specific adhesion interactions, polymorphonuclear leukocytes, macrophages, and lymphocytes penetrate the site of the trauma and lead to an intensive proliferation of fibroblasts, endothelial cells, and keratinocytes. The substances of natural origins based on polyphenolic compounds are possible as a remedy for the normalization of physiological and biochemical parameters in a condition of various pathologies. Phaseolus vulgaris pods extract (PVPE) are an example of a rich source of bioactive compounds with proven human health benefits. Our results revealed imbalance of pro-inflammatory and anti-inflammatory cytokines in esophageal homogenates in rats with alkali burn of esophagus II degree, which can indicate a prolonged inflammation in the burned area. In the groups of animals with the alkaline burn of the esophagus, that were injected extract there can be traced a change of the indicators in the direction of normalization, indicating about the therapeutic effect of aqueous extract of pods of Phaseolus vulgaris.

Research articles

Outcome analysis of acute myeloid leukemia patients treated with high dose daunorubicin

by Dolatkhah R., Jam E., I., Nikanfar A., Esfahani A., Chavooshi S., H., Nejati B., Sanaat Z.

Summary: Acute Myeloid Leukemia (AML) is a malignant hematopoietic disease caused by the presence of a malignant clone in the bone marrow. The classic AML treatment includes a combination of an Anthracycline and Cytarabine. This study aimed to evaluate the effect of high doses of Daunorubicin on patients' outcome.


Effect of yellow stripe scad (YSS) fish consumption on platelet microparticles markers: Can YYS fish be like salmon in overweight healthy individual?

by Abdulrahman Y., Azlan A., Peng L., S., Ismail I., Z., Noor S. M.

Summary: Overweight and obesity is currently a growing burden, according several research data from National Health and Morbidity Survey (NHMS) in Malaysia, shows that in 1999 overweight were at 16,6%, obesity 4.5%; in 2006, overweight were at 29.1%, obesity 14%, in 2011 overweight were, 29.4%, obesity 15.1% and in 2015 overweight were 30%, obesity 17.7%. Suggesting that there is parallel prevalence increase, in this sedentary life style in 2015 compared to 1999. Overweight and obesity affects multiple factor such as shifting lifestyles, urbanization, rising income and influence the genetic make-up of life. Currently, it is a great concerned in Malaysia, because it is a risk factor for most inflammatory disease such as cardiovascular disease, cancer and type 2 diabetes, stroke and chronic inflammatory disease, Recent information by Malaysian health minister, won that the country is facing overweight and obesity pandemic problem showing that half of Malaysian population were either overweight or obese. In addition, the latest estimates from the World Health Organization (WHO), show that almost 14% of the country's citizens fall under the ''obese'' category in Malaysia. A further 40% are overweight. Evidence has shown that PMPs interact with sub-endothelial matrix to mobilise monocytes and neutrophils that favour foam cells formation. PMPs play an important role in the transport and delivery of bioactive molecules that can signal inflammation and promote aberrant angiogenesis in diseases such as atherosclerosis, diabetic retinopathy and cancers in overweight. PMPs may affect target cells either by stimulating them via surface-expressed ligands or by transferring surface receptors from one cell to the others. The modulation effect of omega-3 fatty acid (EPA/DHA) from salmon on platelets and endothelial cell markers has been established. American Heart Foundation in collaboration with Committee on Evaluation, Prevention and Detection recommends 250 to 300 mg of cooked salmon per day for the treatment of high blood pressure and cardiovascular diseases. Yellow stripe scad (YSS) is a local Malaysian fish, recently identified to increase HDL-C in overweight subjects. However, the atheroprotective effect of omega-3 fatty acid from YSS on PMPs markers in overweight and obese healthy individuals is still unclear. Thus, the aim of this article is to explore the nutritional value (EPA/DHA) of YSS Fish fillet on platelet microparticles markers that predetermine overweight and obesity risk factors of atherosclerosis.

Short Communication

Prevalence of blood pressure among students in Jiangsu Province, China

by Musa T., H., Li W., Ahmad T., Jinjin C., Musa H., H., Wei P.

Summary: Obesity and Blood Pressure (BP) is a serious public health issue. The study aims to assess the prevalence of BP and the factors associated with High Blood Pressure (HBP) among student in Jiangsu Province, China.

Research articles

In vitro apoptosis induction ability of methanolic extract of Paramignya trimera root (Xao tam phan) in breast cancer stem cells

by Nguyen S., T., Hung L., V., M., Mai N., T., T., Nhan N., T., Hai N., X., Phan N., K., Dinh K., T., Pham P. V.

Summary: Cancer has been considered as one of the world's leading causes of death. Recently, the Paramignya trimera plant, locally called ``Xao Tam Phan'', has become a popular Vietnamese medicinal herb that is used as alternative medicine for cancer treatment support with minimal side effects. In this study, we aimed to demonstrate the cytotoxicity of methanolic extract of Paramignya trimera on a Vietnamese breast cancer stem cell line (VNBRCA1) in vitro.


Application of electrochemical aptasensors in detection of cancer biomarkers

by Negahdary M., Moradi A., Heli H.

Summary: Today, the late diagnosis of cancers is a big challenge, and using novel diagnostic techniques will provide essential, faster and more accurate treatments. Unfortunately, existing common and traditional diagnostic methods have not been helpful completely and most cancers are diagnosed too late. Recently, researchers have found new diagnostic methods against cancers by aptasensors; these sensory systems can detect involved biomarkers in various cancers so that the research in this field is continued strictly. Aptasensors can detect cancer markers in small quantities and high selectivity; moreover, other advantages of cancer aptasensors such as optimized time and cost saving can be considered. In addition, the aptasensors have been used in the diagnosis of the effective and related factors in cancer therapy follow-up. Here, the most researches about cancer aptasensors and other involved markers were collected, reviewed and described.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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