journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

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Research articles

Outcome analysis of acute myeloid leukemia patients treated with high dose daunorubicin

by Dolatkhah R., Jam E., I., Nikanfar A., Esfahani A., Chavooshi S., H., Nejati B., Sanaat Z.

Summary: Acute Myeloid Leukemia (AML) is a malignant hematopoietic disease caused by the presence of a malignant clone in the bone marrow. The classic AML treatment includes a combination of an Anthracycline and Cytarabine. This study aimed to evaluate the effect of high doses of Daunorubicin on patients' outcome.

Reviews

Effect of yellow stripe scad (YSS) fish consumption on platelet microparticles markers: Can YYS fish be like salmon in overweight healthy individual?

by Abdulrahman Y., Azlan A., Peng L., S., Ismail I., Z., Noor S. M.

Summary: Overweight and obesity is currently a growing burden, according several research data from National Health and Morbidity Survey (NHMS) in Malaysia, shows that in 1999 overweight were at 16,6%, obesity 4.5%; in 2006, overweight were at 29.1%, obesity 14%, in 2011 overweight were, 29.4%, obesity 15.1% and in 2015 overweight were 30%, obesity 17.7%. Suggesting that there is parallel prevalence increase, in this sedentary life style in 2015 compared to 1999. Overweight and obesity affects multiple factor such as shifting lifestyles, urbanization, rising income and influence the genetic make-up of life. Currently, it is a great concerned in Malaysia, because it is a risk factor for most inflammatory disease such as cardiovascular disease, cancer and type 2 diabetes, stroke and chronic inflammatory disease, Recent information by Malaysian health minister, won that the country is facing overweight and obesity pandemic problem showing that half of Malaysian population were either overweight or obese. In addition, the latest estimates from the World Health Organization (WHO), show that almost 14% of the country's citizens fall under the ''obese'' category in Malaysia. A further 40% are overweight. Evidence has shown that PMPs interact with sub-endothelial matrix to mobilise monocytes and neutrophils that favour foam cells formation. PMPs play an important role in the transport and delivery of bioactive molecules that can signal inflammation and promote aberrant angiogenesis in diseases such as atherosclerosis, diabetic retinopathy and cancers in overweight. PMPs may affect target cells either by stimulating them via surface-expressed ligands or by transferring surface receptors from one cell to the others. The modulation effect of omega-3 fatty acid (EPA/DHA) from salmon on platelets and endothelial cell markers has been established. American Heart Foundation in collaboration with Committee on Evaluation, Prevention and Detection recommends 250 to 300 mg of cooked salmon per day for the treatment of high blood pressure and cardiovascular diseases. Yellow stripe scad (YSS) is a local Malaysian fish, recently identified to increase HDL-C in overweight subjects. However, the atheroprotective effect of omega-3 fatty acid from YSS on PMPs markers in overweight and obese healthy individuals is still unclear. Thus, the aim of this article is to explore the nutritional value (EPA/DHA) of YSS Fish fillet on platelet microparticles markers that predetermine overweight and obesity risk factors of atherosclerosis.

Short Communication

Prevalence of blood pressure among students in Jiangsu Province, China

by Musa T., H., Li W., Ahmad T., Jinjin C., Musa H., H., Wei P.

Summary: Obesity and Blood Pressure (BP) is a serious public health issue. The study aims to assess the prevalence of BP and the factors associated with High Blood Pressure (HBP) among student in Jiangsu Province, China.

Research articles

In vitro apoptosis induction ability of methanolic extract of Paramignya trimera root (Xao tam phan) in breast cancer stem cells

by Nguyen S., T., Hung L., V., M., Mai N., T., T., Nhan N., T., Hai N., X., Phan N., K., Dinh K., T., Pham P. V.

Summary: Cancer has been considered as one of the world's leading causes of death. Recently, the Paramignya trimera plant, locally called ``Xao Tam Phan'', has become a popular Vietnamese medicinal herb that is used as alternative medicine for cancer treatment support with minimal side effects. In this study, we aimed to demonstrate the cytotoxicity of methanolic extract of Paramignya trimera on a Vietnamese breast cancer stem cell line (VNBRCA1) in vitro.

Reviews

Application of electrochemical aptasensors in detection of cancer biomarkers

by Negahdary M., Moradi A., Heli H.

Summary: Today, the late diagnosis of cancers is a big challenge, and using novel diagnostic techniques will provide essential, faster and more accurate treatments. Unfortunately, existing common and traditional diagnostic methods have not been helpful completely and most cancers are diagnosed too late. Recently, researchers have found new diagnostic methods against cancers by aptasensors; these sensory systems can detect involved biomarkers in various cancers so that the research in this field is continued strictly. Aptasensors can detect cancer markers in small quantities and high selectivity; moreover, other advantages of cancer aptasensors such as optimized time and cost saving can be considered. In addition, the aptasensors have been used in the diagnosis of the effective and related factors in cancer therapy follow-up. Here, the most researches about cancer aptasensors and other involved markers were collected, reviewed and described.

Short Communication

Apolipoprotein E gene polymorphism influenced glycemic status among Malaysians

by Rahman K. M. H., Hossain M.,. S., Haque N., Razak T., B., A., Ahmad H.

Summary: In the last decade Apolipoprotein E (APOE) gene polymorphism has been identified as one of the risk factors of type 2 diabetes mellitus (T2DM). Though more than 11% population of Malaysia are suffering from T2DM, there is inadequate data on the correlation between the APOE gene polymorphism and pathogenesis of diabetes among Malaysians. Hence, in this study we aimed to find out the association between the frequencies of APOE allele and fasting blood glucose (FBG) concentration among subjects with T2DM.

Research articles

Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats

by Akhter F., Sultan Alvi S., Ahmad P., Iqbal D., Alshehri B., M., Khan M. S.

Summary: We have previously demonstrated that sequentially extracted methanolic fractions of Boerhaavia diffusa (Linn.) showed marked antioxidant, antidiabetic and oxidative-DNA damage protective properties in vitro. The present study was undertaken to evaluate the beneficial effects of B.diffusa (Linn.) methanolic root extract and its partially purified bioactive fraction on streptozotocin (STZ)-induced hyperglycemia and hyperlipidemia in rats.

Research articles

Low levels of serum complement factor H is associated with increasing progression of bronchiectasis

by Shettima A., Ibrahim M.

Summary: Complement Factor H (CFH) is the major soluble regulatory protein that monitors activation and/or amplification of the complement system. Here, we assess serum levels of complement factor H (CFH) among patients, who were diagnosed with bronchiectasis.

Research articles

Prevention and treatment of brain damage in streptozotocin induced diabetic rats with Metformin, Nigella sativa, Zingiber officinale, and Punica granatum

by Sangi S., M., A., Jalaud N. A. A.

Summary: Diabetes mellitus (DM) is well-known metabolic disorder, which causes serious effects on human health with its complications. Many mechanisms has been postulated to cause DM related complications. One of the main complications is neuronal damage, for which no proper preventive and curative therapies are available.

Research articles

Orally administered fisetin as an immuno-modulatory and therapeutic agent in a mouse model of chronic allergic airway disease

by Paul P., Majhi S., Mitra S., Banerjee E. R.

Summary: Allergic asthma is a prevalent disorder, in which eosinophilic inflammation is involved in the lungs. Asthma affects people all over the world, regardless of the country's level of development. Chronic allergen-induced fibrotic damage of the lungs is stimulated in 55 days, which results in significant tissue destruction constitutive to pulmonary tissues, in addition to extensive oxidative & inflammation-induced damage of small and large airways. To date, there is no cure for asthma, and symptoms are controlled using corticosteroids, which may cause systemic side effects. Flavonoids, like fisetin, are a class of secondary metabolites produced by plants, which are known to have numerous beneficial effects. Previous report demonstrated that fisetin has beneficial effects against various diseases such as cancers, tumors, diabetes, and alcohol-induced liver injury.

Reviews

Pre-diagnostic role of platelet miRNA in coronary heart disease of healthy overweight subjects via platelet leptin receptor activation

by Abdulrahman Y., Azlan A., Peng L., S., Noor S. M.

Summary: Obesity and overweight have become a global problem that development of various coronary artery diseases (CAD), such as myocardial infarction, atherosclerosis and congestive heart failure. Effective diagnosis is needed for effective treatment and prevention, particularly in healthy overweight subject. Platelets is an important component of hemostatic balance, that maintains the coagulation physiology. Platelets are involved in different pathological events such as thrombosis and CAD in various inflammatory conditions. There are evidences that highlight an important role of miRNA in regulation of gene expression profiling in platelets. Current hypothesis has shown the likelihood of using miRNAs as diagnostic markers in the event of CAD. This review article describes the association between overweight/obesity and platelets activation in elucidating the gene expression profiling in platelet miRNAs in CAD patient. The application of platelet miRNAs as predictive markers in overweight/obese individuals may become a marginal milestone in the history of this diet-related disorder treatment.

Research articles

Comparison of the efficacy of two types of hemodialysis catheters: the VectorFlow vs. Palindrome catheters

by Ali V., MohammadReza S.

Summary: Permanent vascular access via catheters is a critical factor for patients who need long-term hemodialysis. Differences in the design and mechanical factors can affect efficacy and survival of the permanent catheters. Modifications in the designs of the catheters can decrease the likelihood of damaging blood vessels as well as thrombosis formation and malfunction of the catheters.

Research articles

Centella asiatica prevents chronic unpredictable mild stress-induced behavioral changes in rats

by Jagadeesan S., Musa Chiroma S., Baharuldin M., T., H., Taib C., N., M., Amom Z., Adenan M., I., Moklas M. A. M.

Summary: Depression is a psychological disorder which is associated with mood swings and cognitive deficits, and is ranked third among the leading causes of global health care burden. Chronic unpredictable mild stress (CUMS) has been shown to induce depression-like behaviors in rodents, which exhibit similarities to the human form of depression. Centella asiatica (CA) is an ancient medicinal plant which has neuroprotective potential. This work aimed to assess the protective role of CA on CUMS-induced rats.

Research articles

Recombinant human granulocyte colony-stimulating factor alleviates liver fibrosis in bile duct-ligated mice

by Do H., Q., Le T., V., Dang M., T., Pham-Le T.,-T., Tran L., V., Huynh K., C., Le Holterman A.,-X., Truong N. H.

Summary: Biliary atresia (BA) is the leading cause of liver fibrosis and failure in neonates with surgical jaundice, leading to poor outcome. Clinical and animal studies showing that granulocyte colony-stimulating factor (GCSF) treatment could improve liver fibrosis and cirrhosis suggest that GCSF may be offered as a low-cost intervention to improve the course of BA. This study aims to test the hypothesis that 10 µg/kg/day x 5 days of GCSF could improve liver function, reduce molecular pro-fibrotic markers and decrease liver fibrosis in a mouse model of bile duct ligation (BDL).


 

 

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Editors' quote

 

Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.
 
 

Affiliation

Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.
 
 
 

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