journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. 

Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics.

Biomedical Research and Therapy is indexed and abstracted in major databases included Web of Science (ESCI - Emerging Sources Citation Index, Clarivate Analytics), Scopus (Elsevier), Embase, ...

The journal is published monthly, 12 issues per year.

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Featured Articles

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Research articles

Mesenchymal stem cells accelerate liver regeneration in acute liver failure animal model

by Putra A., Antari A., D., Kustiyah A., R., Intan Y., S., N., Sadyah N., A., C. Wirawan N., Astarina S., Zubir N., Munir D.

Summary: The massive hepatic necrosis of acute liver failure (ALF) results in a sudden loss of hepatic cells. Although most hepatocyte cells of ALF are completely lost, stem cell-derived circulating cells and endogenous progenitor cells rapidly regenerate them. Mesenchymal stem cells (MSCs) have a critical role in the regeneration of liver injury through regulating platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) levels. However, their fluctuating levels in the healing process and correlation to the decrease of liver function markers remain unclear. The aim of this study was to analyze the effects of MSCs in accelerating liver regeneration of ALF by measuring VEGF and PDGF levels on day 2 and 7, as well as SGPT and SGOT levels, and assessing histopathology appearance.

Case report

Non-syndromic multiple impacted teeth: two case reports

by Delavarian M., Delavarian F., Imani M. M.

Summary: Multiple impacted permanent teeth is a rare finding and often associated with systemic diseases or some rare syndromes. This article reports two Iranian cases with multiple impacted teeth without systemic disease or syndromes. The first patient, a 17-year-old male, had 18 unerupted teeth and 9 unerupted supernumerary teeth. The second patient, a 16-year-old female, had 14 unerupted teeth. In these cases, an interdisciplinary approach between orthodontist, oral surgeon and prosthodontist is required to achieve optimum facial aesthetics and functional occlusion.


Correction to: Insertion / Deletion Polymorphism of Angiotensin Converting Enzyme Gene Does Not Contribute to Chronic Kidney Disease in Palestine

by Abuaisha A., M., Marzoq L., F., A., Eljbour M., S., Fayyad E., S., Baraka A., K., Serakinci N.


Research articles

Survival analysis of liver cirrhosis patients after transplantation using accelerated failure time models

by Abolghasemi J., Toosi M., Rasouli M., Taslimi H.

Summary: Liver transplantation is known as the only treatment for advanced liver cirrhosis. Considering the importance of identifying the factors affecting the survival of cirrhosis patients after transplantation in order to improve the health of these patients and increase their longevity, this study was conducted to fit the best accelerated failure time model for survival analysis of cirrhosis patients.

Research articles

Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease and its correlation with disease severity

by Moayyedkazemi A., Rahimirad M. H.

Summary: It has been proven that patients with chronic obstructive pulmonary disease (COPD) are at risk for increased atherothrombotic events. Studies have demonstrated that C-reactive protein (CRP) and COPD are risk factors for heart disease. The present study aimed to evaluate the serum level of CRP in patients with COPD and compare it with those of the control group.

Research articles

Efficacy of adding Luvos® Healing Earth supplementation to mebeverine in improving symptoms and quality of life of patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial

by Mokhtare M., Asadipanah M., Bahardoust M., Chaharmahali A., Sikaroudi M., Khoshdelnezamiha M., Davanloo F., Masoodi M., Bahadorizadeh L.

Summary: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Treatment can improve symptoms and social functioning in the patients. This study was designed to assess the effect of adding Luvos supplementation to mebeverine on improving symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable bowel syndrome.

Research articles

The effect of delivery type on neonatal blood indices in an Iranian population

by Baharvand P., Fathi M., Eliyasy H., Abdolkarimi B., Kiani A.

Summary: Generally, there are two methods for childbirth: normal vaginal and cesarean section (C-section). Each method has advantages and complications. In this study, we investigated the effects of type of delivery on hematological parameters in healthy full-term neonates in an Iranian population, from 2016-2017.

Research articles

Evaluation of butyrylcholinesterase and acetylcholinesterase activity in serum and saliva of myocardial infarction patients

by Omidpanah N., Jalilian N., Vaisi-Raygani A., Sadeghi M., Mozaffari H.

Summary: Myocardial infarction (MI) is one of the most common cardiovascular diseases. It accounts for about half of death cases in Iran. The objective of this study was to compare the activity of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) enzymes in serum and saliva of the MI patients compared to the healthy controls.

Research articles

The effects of Matricaria chamomilla L.hydroalcoholic extract on atherosclerotic plaques, antioxidant activity, lipid profile and inflammatory indicators in rats

by Nargesi S., Moayeri A., Ghorbani A., Seifinejad Y., Shirzadpour E., Amraei M.

Summary: Treatment of cardiovascular risk factors seems to be necessary and involves a number of changes in drug treatment and lifestyle. This study aimed to evaluate the effects of Matricaria chamomilla L. hydroalcoholic extract on antioxidant activity, atherosclerotic plaques, lipid profile and inflammatory indicators in rats.

Research articles

Antinociceptive and anti-inflammatory effects of Amygdalus eburnea shell root extract in mice

by Galehdar N., Rezaeifar M., Rezaeifar M., Rezaeifar M.

Summary: The current study aims to assess the antinociceptive and anti-inflammatory activities of Amygdalus eburnea Spach extract in mice.

Research articles

Physiological and biochemical studies on the protective effect of Ficus carica leaf extract, vitamin C or their combination on liver toxicity induced by lead acetate in male rats

by Diab A., Zahra M., Attia M., Shehata A.

Summary: Lead is an environmental contaminant, which is toxic to organ systems in human and other animals. The present study investigated the possible protective role of Ficus carica leaf extract, vitamin C or the combined treatment in lead acetate-induced hepatotoxicity.

Research articles

Efficacy of intrathecal midazolam on enhancing analgesic effect of fentanyl in patients undergoing lower limb surgery

by Khoshfetrat M., Davarpanah S., Keykha A.

Summary: Co-administration of drugs with synergistic effects is considered as one of the methods to increase the effectiveness of intrathecal anesthesia and to reduce the need for injectable analgesics. The purpose of this study was to investigate the efficacy of intrathecal midazolam on enhancing the analgesic effect of fentanyl in patients undergoing lower limb surgery.

Research articles

Comparing the duration of spinal anesthesia with bupivacaine between drug-dependent and non-dependent patients

by Beirami F., Khoshfetrat M., Khosravi H., Keykha A.

Summary: Drug abusers have much lower pain threshold, in a way that the duration of the effect of anesthesia on controlling their pain is still not fully known. Therefore, this study aimed to compare the duration of spinal anesthesia induced with bupivacaine between drug-dependent and non-dependent individuals.

Letter to Editor

Rabies in Asian Countries: Where we are stand?

by Ahmad T., Musa T., H., Jin H.

Summary: Rabies is one of the neglected zoonotic disease in Asian and African countries. This article highlights the rabies death rate in Asian countries during 2010-2014. High death rate was reported in China, Philippine and Vietnam. The overall death rate has dropped since 2010 to 2014 but still the disease is prevalent in some Asian countries. Reinforcement of the rabies surveillance is needed to strengthened national, regional and global reporting system to control and eliminate the disease by 2030.

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Stem Cells and Regenerative Medicine
The collections of published articles about stem cells as well as regenerative medicine. 
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Special Issues 
Biomedical Research and Therapy would like to invite guest editors to contribute special issue. 
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Natural Extract
The collections of published articles about herbal, natural products. 
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The best original research articles
Every year, all authors published their studies as Original research in Biomedical Research and Therapy can join this awards.
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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.


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