journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

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Research articles

The frequency and risk factors of low bone mineral density one year after liver transplantation in children: a study in Shiraz Organ Transplant Center

by Dehghani S., M., Amirhakimi A., Shahramian I., Bazi A., Hashemi M., Ilkhanipour H.

Summary: Osteoporosis is a severe epiphenomenon that follows liver transplantation (LT). There is an inconsistency regarding risk factors of developing osteoporosis in LT children. In this article, we address the frequency of low bone mineral density (BMD) in LT children.


Variations of anterior and posterior division of internal iliac artery: A systematic review and clinical implications

by Mohammadbaigi H., Darvishi M., Moayeri A.

Summary: The distribution pattern of internal iliac artery (IIA) implies its bifurcation to two branches, the anterior and the posterior trunks. According to previous research, IIA indicates several anatomical variations. The purpose of this study is to evaluate the types of these variations. The presence of these variations in the arteries is an important topic to urologists, gynecologists, radiologists, and general surgeons because they can be ruptured during surgical procedures in the perineal and pelvis region. Three databases were searched for the period from 1810 to January 2018 and a total of 75 studies were investigated. This study evaluated the branching of the internal iliac artery in several literatures and compared it with Adachi's classification. This finding can lead to improve surgical technique and safety in medical practice.

Case report

Management of two taurodont primary molars with pulp involvement using calcium-enriched mixture cement pulpotomy in a patient with accompanied drug reaction with eosinophilia and systemic symptoms syndrome: a case report

by Kamareh S., Kazem M., Foroozandeh M., Gohari A.

Summary: Taurodontism is considered a variation in tooth morphology associated with several syndromes.

Case report

A revolution in the treatment of aggressive liposarcoma by pazopanib combined with chemotherapy- A case report

by Payandeh M., Karami A., Rahimi S., Karami N., Aeinfar M.

Summary: Pazopanib is a new tyrosine kinase inhibitor which acts as anti-VEGF signaling and antiangiogenesis. In some countries, this drug has been approved for the treatment of advanced, or metastatic soft tissue sarcoma. Nevertheless, the efficacy of Pazopanib has not yet been proven in patients with advanced liposarcoma. We reported a rare case of advanced liposarcoma that after several courses of chemotherapy, the disease was relapsed, and CT-scan results showed lung metastasis. Therapeutic measures, including surgery and chemotherapy with pazopanib, were successful in destroying the metastatic mass in the patient's lung. Our finding provides a new therapeutic approach for pleomorphic liposarcoma.

Research articles

Short-term clinical outcomes in patients with acute myocardial infarction after successful percutaneous coronary revascularization: the role of promoter polymorphism of the endothelial nitric oxide synthase gene

by Petyunina O., Kopytsya M., Babichev D., Berezin A.

Summary: The purpose of this study was to investigate the associations between variants of a promoter polymorphism of the endothelial nitric oxide synthase (eNOS) gene and clinical outcomes in acute ST-segment elevation myocardial infarction (STEMI) patients after a successful primary percutaneous coronary artery intervention (PCI).

Research articles

Hepatoprotective and nephroprotective effects of Trigonella foenum-graecum L. (Fenugreek) seed extract against sodium nitrite toxicity in rats


Summary: Feeding habits and environmental factors may rival genetic susceptibility as etiological factors related to various cancers. Humans are continuously exposed to many synthetic food additives, one of which is sodium nitrite (NaNO2). There is a direct correlation between increases in consumption of nitrite-treated products and incidence of tissue damage, hepatotoxicity, nephrotoxicity and some types of cancer. The objective of this study was to investigate the protective effects of Trigonella foenum-graecum (TFG) on NaNO2-induced hepatotoxicity and nephrotoxicity.

Research articles

Comparison of the efficacy of using paclitaxel-eluting balloon and plain balloon angioplasty for arteriovenous fistula in hemodialysis patients

by Rai A., Sobhiyeh M.

Summary: Arteriovanous (AV) access failure is one of the main problems in patients with end stage renal disease (ESRD), who receive hemodialysis. Balloon angioplasty is a favorable method for managing vascular access failure. The purpose of this study was to compare the six-month efficacy of paclitaxel-eluting balloon and plain balloon angioplasty in failed AV access cases among hemodialysis patients.

Research articles

Lack of association between 4 key TNF-alpha promoter polymorphisms and hepatitis C virus infection in a population of Egyptian patients

by Ghoneim A.

Summary: With 170 million chronic hepatitis C virus (HCV) cases worldwide, HCV is considered a major life-threatening pathogen. HCV is a crucial causative of liver cirrhosis and hepatocellular carcinoma. Tumor necrosis factor-alpha (TNF-alpha) is thought to be a mediator in the development of viral hepatitis. Because HCV is epidemic in Egypt, this study aimed to characterize the distribution of TNF-alpha gene promoter polymorphisms and their relation to TNF-alpha expression in HCV patients.


Glycan regulation in cancer, nervous and immune system: A narrative review

by Haider Khan H., Shi B., Tian Y., Wang T., Hussain S., Ullah Khan F., Khan Z., Ashfaq B., Ahmad H., Ahmad T.

Summary: Glycans are carbohydrate components of glycoconjugates, which interact with their receptors; for example, galectins and C-type lectins. The specificity to their receptors makes them the ideal biomarkers that they can be used as a therapeutic target or as a screening tool. We collected and reviewed articles from different databases, which show that glycans play a significant role in several body functions, such as stimulation of the immune system, and can be used in the differentiation among cancer types. They also help in nervous system repair, regeneration, regulation and proliferation. Furthermore, several pathogens like Schistosoma, HIV, Influenza, Candida, and Ebola produce glycoproteins to aid in the invasion via attachment to surface glycoproteins and defend themselves against the host's immune system.

Research articles

Comparison of biomarkers between genotypes 1a and 3a in hepatitis C virus patients with control group

by Yazdansetad S., Razavi Nikoo H., Azimi S., M., Mohebbi A., Niazi M., Ajorloo M.

Summary: Three percent of people worldwide are infected with Hepatitis C virus (HCV). A few studies have been performed to evaluate the biochemical markers of the disease. In the current study, biochemical markers were evaluated in HCV patients and the control group.

Research articles

The subpopulation of CD105 negative mesenchymal stem cells show strong immunomodulation capacity compared to CD105 positive mesenchymal stem cells

by Pham L., H., Vu N., B., Van Pham P.

Summary: Human mesenchymal stem cells (MSCs) are the most popular stem cells applied in disease treatment. MSCs can be isolated and in vitro expanded from various sources such as bone marrow, peripheral blood, umbilical cord blood, umbilical cord tissue, and adipose tissue. According to Dominici et al. (2006), MSCs should express CD105, an essential marker used to confirm MSCs. However, some recent studies have show that MSCs contained a subpopulation that is negative for CD105. This study aimed to compare the immune modulation capacity of 2 populations of CD105 positive (CD105+) and negative (CD105-) MSCs derived from 2 sources: human adipose tissue (AT) and human umbilical cord (UC).


CORRECTION: A type 2 diabetes mellitus patient was successfully treated by autologous bone marrow-derived stem cell transplantation: A case report

by Le P., T.,-B., Doan N., P.,-V., Tien P., V., Hoang D., N., C., Phan N., K., Pham P. V.

Summary: In the previous publication with title ”A type 2 diabetes mellitus patient was successfully treated by autologous bone marrow-derived stem cell transplantation: A case report”1, page 2968, in the Table 1, the unit for fasting blood glucose and blood glucose 2 hours after meals is mg/dL; however, the corrected unit for fasting blood glucose and blood glucose 2 hours after meal is mmol/L.

Research articles

Effect of Vitamin D deficiency in lower extremity and pulmonary venous thromboembolism

by Dehghani K., Nowrouzi A., Hossein Pourdavood A., Rahmanian Z.

Summary: Vitamin D deficiency increases inflammation and dysfunction of pancreas betacells, resulting in atherosclerotic disorders, cerebrovascular disorder, and CVDs.

Research articles

Cytology-histology correlation of gynecologic and non-gynecologic samples at a tertiary health care center: A two-year study

by Raju K., Megalamane Sunanda S., Shree Rajanna V.

Summary: Cytology-histology correlation is a method of detection of an error in the diagnostic field. The root cause analysis is done for the discordant cases for quality improvement of the laboratory reports. Aims: To find out the root cause in discordant cytology-histology case pairs.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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