journal description

Biomedical Research and Therapy (ISSN 2198-4093) is the major forum for basic and translational research into therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports. Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. The journal is published monthly, 12 issues per year.

Biomedical Research and Therapy is indexed and abstracted in major databases included: 


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Featured Articles

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Research articles

Efficacy of topical cinnamon gel for the treatment of facial acne vulgaris: A preliminary study

by Ghovvati M., Afshari G., K., Nasrollahi S., A., Firooz A., Samadi A., Karimi M., Talebi Z., Kolahdooz S., Vazirian M.

Summary: Acne vulgaris is a common chronic disorder of the pilosebaceous unit. Topical therapy is the mainstay of treatment for mild-to-moderate acne. Two main problems with conventional anti-acne treatments are antibiotic resistance and local side effects. In this regard, medicinal herbs could be an alternative choice for developing new products with fewer side effects. Objective: The purpose of this study was to evaluate the safety and efficacy of a topical formulation of cinnamon in patients with facial acne.

Research articles

Effects of porcine granulocyte-macrophage-colony-stimulating factor on porcine cumulus-oocyte complex maturation in vitro

by Dang L., Le T.,-T., Huynh C., Hoang S.

Summary: The in vitro maturation (IVM) of oocytes is an essential step in the in vitro embryo production. This study aimed to improve the efficacy of IVM by supplementing with granulocytemacrophage colony stimulating factor (GM-CSF) in the culture medium.


The use of nootropics in Alzheimer’s disease: is there light at the end of the tunnel?

by Chiroma S., M., Taib C., N., M., Moklas M., A., M., Baharuldin M., T., H., Amom Z., Jagadeesan S.

Summary: The nootropic or simply known as smart drug is a common term given to any compound that is responsible for enhancing mental capability or performance. Alzheimer's disease is characterized clinically by lose of cognitive abilities and pathologically by two hallmark lesions, neurofibrillary tangles and senile plaques. It is unfortunate that AD has no cure yet. In this review attempt has been made to elucidate the general views on AD pathogenic hypotheses and common nootropics being used in AD research.

Research articles

Risk factors of peripheral neuropathy in patients with type 2 diabetes in Isfahan: Results of a cohort study in Iran

by Mohammadian-Hafshejani A., Majdzadeh R., Mansournia N., Mansournia M. A.

Summary: Peripheral neuropathy (PN) is among the most prevalent complications of diabetes that can lead to impairment of mobility of diabetic patients. The purpose of the current study was to predict relative factors influencing the occurrence of peripheral neuropathy (PN) in patients with type 2 diabetes.

Research articles

Revisiting Prostate Biopsy with 2014 ISUP Modified Gleason Score and Gleason Grade – A Cross Section Study

by Shah M., B Raju K., Kumar G H.

Summary: Prostatic carcinoma is one of the most common carcinomas among men throughout the world. Gleason score (GS) system is used in reporting and assessing the prognosis of prostatic carcinoma. The GS has undergone modifications. The objective of this study is to evaluate the impact of the new 2014 ISUP Modified Gleason System and Gleason grading (GG) on reporting of prostatic carcinoma.

Research articles

Comparison of clinical outcome of frozen embryo transfer after embryo selection based on morphokinetic versus morphologic criteria for freezing

by Quang L., N., Tram L., T., B., Thuy N., H., M., Toan P., D., Vinh D., Q., Huyen N. T. T.

Summary: Results from the latest meta-analysis, in fresh cycles, showed that the application of time-lapse monitoring (TLM) together with an embryo-evaluating algorithm was associated with a significantly higher rate of ongoing pregnancy and a lower rate of early pregnancy loss. The aim of this study was to compare the clinical outcomes of frozen embryos classified according to morphokinetic versus morphologic criteria.


The role of brain natriuretic peptides as a marker for diagnosing cardiac syncope: A narrative review

by Disfani H., F., Kamandi M., Rahmani K.

Summary: Cardiac disease is the second common cause of syncope in emergency departments. Patients with Cardiac syncope have a higher risk of mortality than those who have a non-cardiac problem. Brain natriuretic peptide (BNP) as a cardiac marker has not thoroughly been evaluated in patients with syncope. This article focuses on the studies that have assessed BNP and NT-pro-BNP in cardiac and non-cardiac syncope patients in emergency departments.

Research articles

Cyclosporine-A induced nephrotoxicity in male and female rats: Is zinc a suitable protective supplement?

by Choopani S., Kasaei S., Talebi A., Mortazavi M., Gheisari Y., Matinfar M., Nematbakhsh M.

Summary: Cyclosporine (CYC) is an immunosuppressant drug used widely in kidney transplant patient. The major side effect of CYC is nephrotoxicity. In this study, three different doses of CYC alone or accompanied with zinc (Zn) supplement were administrated in male and female rats to determine the kidney tissue damages and functions.

Research articles

Effects of prophylactic ketamine and pethidine to control postanesthetic shivering: A comparative study

by Khoshfetrat M., Jalali A., R., Komeili G., Keykha A.

Summary: Shivering is an undesirable complication following general anesthesia and spinal anesthesia, whose early control can reduce postoperative metabolic and respiratory complications. Therefore, this study aims to compare the effects of prophylactic injection of ketamine and pethidine on postoperative shivering.

Research articles

Effects of aqueous extract of polyherbal formulation against hyperthyroidism induced by L-thyroxin in a rat model

by Ahmed S., B. Moghazy A., M. Ahmed-Farid O., A. Esebery H. A.

Summary: Hyperthyroidism is a disorder that occurs when the thyroid gland secretes more thyroid hormone than the body needs. Thyroid hormone is essential for the normal growth and development of normal organs. Polyherb (POH) formulation has proven to be useful in number of diseases and has been used in folk medicine as an anti-hyperthyroidism, anti-oxidant, and appetitestimulating agent. The aim of the study was to evaluate the curative effect of POH against L-thyroxin (LT4)-induced hyperthyroidism in male rats.

Research articles

Elevated levels of circulating soluble ST2 at discharge predict late adverse ventricular remodeling in patients with ST-segment elevation myocardial infarction

by Petyunina O., V. Kopytsya M., P. Berezin A. E.

Summary: The aim of this study was to investigate whether the circulating level of sST2 would predict adverse LV remodeling in STEMI patients with TIMI III flow through the myocardial infarctrelated coronary artery six months after intervention.

Research articles

Clinical, microbiological research of the effectiveness of inhalation use of quaternary ammonium antiseptic in the prevention and treatment of infectious respiratory complications in critically ill patients

by Nazarchuk O., A. Dmytriiev D., V. Dmytriiev K. D.

Summary: The aim is to study the microbiological and clinical efficacy of decamethoxinebased quaternary ammonium antiseptic inhalations in the complex management of respiratory infectious complications in critically ill children.

Research articles

Development and evaluation of 12-lead electrocardiogram in the left free wall of accessory pathway localization in patients with typical Wolff-Parkinson-White syndrome

by Chu S., Pham K., Tran D.

Summary: This study was designed to characterize 12-lead electrocardiogram (ECG) for localization of the left free wall lateral accessory pathway (AP) in patients with typical Wolff-Parkinson-White (WPW) syndrome, to develop a new algorithm ECG for localizing APs, and to test the accuracy of the algorithm prospectively.

Research articles

Anodal transcranial direct current stimulation enhances positive changes in movement functions, visual attention and depression of patients with chronic ischemic stroke: A clinical trial

by Hosseinzadeh S., A., Mazhari S., Najafi K., Ahmadi M., Aghaei I., Khaksarian M.

Summary: Stroke is one of the most serious and debilitating diseases in our society. Stroke survivors can suffer several neurological impairments. They typically show pathological changes in neural functions of brain areas. Transcranial direct current stimulation (tDCS) can be applied to modify cerebral excitability and has been recently applied in the treatment of neuropsychological and neurological disorders. The aim of the study herein was to evaluate changes in movement and cognitive functions of chronic ischemic stroke patients using anodic and cathodic tDCS.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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