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Expression of P16 biomarker in squamous cell carcinoma of uterine cervix and its association with clinico-pathological parameters: A cross-sectional study
by R.
K.,
C.V.
R.,
S.R.
S.
Summary: Cervical cancer is the most common cancer among females. P16 is the surrogate marker for cervical carcinoma. This study aimed to evaluate the association of P16 marker with clinic-pathological parameters in squamous cell carcinoma of uterine cervix.
Novel immunogenomic insights of corona virus disease (COVID-19): Available potential immunotherapeutics, current challenges, immune cell recognition and ongoing managerial strategies
by Haneef
K.,
Asghar
M.,
Ali
A.
Summary: The emerging Corona virus strain (severe acute respiratory syndrome corona virus-2 (SARS-CoV-2)) harbors intricate in the development of corona virus infection (COVID-19)-induced pneumonia and subsequently ameliorates lung infection. Genome sequence and interventions reveal proximal resemblance of corona virus strain COVID-19 with severe acute respiratory syndrome (SARS), transmittable to bats, suggesting similar primary hosts in the spread of infection. However, potential rapid human-to-human transmission has caused therapeutic challenges in treating a wide range of humans suffering from corona virus all over the world. However, up to now, no direct vaccines or antiviral drugs are available to treat COVID-19. Previously designed antiviral drugs and convalescent plasma are undergoing investigations as treatment for COVID-19 infected patients. Therapeutic challenges with regards to COVID-19 have prompted scientists to develop fruitful remedies to combat the pathogen. In this review, we address the role of current ongoing therapeutic strategies, , and complex mechanisms of adaptive immune system (B and T cells) to respond to viruses. Furthermore, we illustrate the current challenges in the treatment of COVID-19, managerial strategies, and ongoing and future perspectives.
Prevalence and in vitro antibiotic susceptibility pattern of bacterial strains isolated from tribal women suffering from urinary tract infections in District Anuppur, Madhya Pradesh, India
by Sharma
P.,
Netam
A.,
Singh
R.
Summary: Urinary tract infections (UTIs) are an increasing public health problem caused by a range of uropathogens. UTI is a major health concern among tribal women due to lack of adequate health facilities at regional public health centers and district hospitals. The objective of the study was to investigate the prevalence and antibiotic susceptibility of bacteria isolated from urine samples of tribal women suffering from UTI. Urine samples were collected from 550 tribal women who visited the Outpatient Department (OPD) of the District Hospital of Anuppur, Madhya Pradesh, India.
Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?
by Shilpa
M.,
Kalyani
R.,
Sreeramulu
P N
Summary: The most common malignancy which endangers the quality of life in females is breast cancer. It is also the major public problem in society and despite advances in treatment strategies, it still leads to high mortality. In all breast cancer patients, the first assessment done before surgery is the complete blood count (CBC). There exists a strong relationship between immune response of the body and clinical staging of breast cancer. This study aimed to determine the most reliable hematological markers for the prognosis of breast cancer, and to evaluate the correlation between hematological parameters and disease staging.
Brain-derived neurotrophic factor gene polymorphism in post-ST-elevation myocardial infarction patients undergoing primary percutaneous intervention
by Petyunina
O.,
Kopytsya
M.,
Berezin
A.
Summary: The goal of this study was to elucidate a link of brain-derived factor (BDNF) Val66Met gene with combined 6-month clinical end points in post-myocardial infarction patients.
Correlation of serum fluorescence of advanced glycation end products with diabetes duration and glycemic control in type 2 diabetic patients
by Ali
S.,
Rao
N.
Summary: Advanced glycation end products (AGEs) and diabetes duration have roles in the development of the vascular complications associated with morbidity and mortality in diabetic patients. The present study was conducted to estimate and find the association between serum fluorescence levels of advanced glycation products with diabetes duration and glycemic control in type 2 diabetic patients.
Comparison of ultrasonography and X-ray test for lateral malleolar fracture in ankle sprain
by FeizDisfani
H.,
Bolvardi
E.,
Shourabi
M.,
Sharifi
M.,
Mousavi
S.,
Farzaneh
R.
Summary: The use of ultrasonography for diagnosing musculoskeletal injuries, especially fractures, in the emergency department is on the rise because of its good diagnostic value. This study aimed to evaluate the diagnostic value of bedside ultrasonography in detecting the patients suffering from lateral malleolar fractures with an ankle sprain mechanism.
Oral cavity and lip cancer in the world: An epidemiological review
by Salehiniya
H.,
Raei
M.
Summary: One of the most common cancers is squamous cell carcinoma of the head and neck which is a serious health challenge worldwide. Considering the importance of knowledge of incidence, death and risk factors in prevention programs, this study was conducted to investigate the incidence, mortality and risk factors for oral cavity and lip cancer in the world.
Safety assessment of essential oils from Xylopia aethiopica (Dunal) fruit from Nigeria
by Ekeanyanwu
R.,
Mgbedo
N.,
Njoku
A.
Summary: The essential oils of Xylopia aethiopica fruits have been reported to possess numerous biochemical effects. However, no toxicological data is available regarding the safety evaluation of the essential oils from the plant spice. The present study was performed to evaluate the safety of essential oils from X. aethiopica (XAEO) fruit by acute and sub-acute oral toxicity studies in experimental rodents.
COVID-19 around the world and the Chinese strategy to cope with SARS-CoV-2
by Shereen
M.,
Ullah
H.,
Khan
S.,
Bashir
N.,
Kazmi
A.,
Saif
K.,
Qudus
M.
Summary: SARS-CoV-2, a zoonotic virus, emerged in China causes Coronavirus Disease-2019 (COVID-19). Senior citizens and people with co-infections, genetic diseases, immune-compromised states, and cardiovascular diseases are at higher risk. There is no approved vaccine or drug available to treat COVID-19, although a few antivirals, interferon, and other drugs have reduced viral load in infected patients. However, these drugs have not been significantly effective in European countries. More than 40 different strains of SARS-CoV-2 have been detected in various parts of the world; they might have adapted themselves to the environmental conditions and have become resistant to therapeutic strategies. Many developed and developing countries are facing shortages of surgical masks and other protection tools. So far, the strategies developed by Chinese authorities have efficiently mitigated the SARS-CoV-2 transmission and limited mortality rate to less than 4%, with more than 78,000 people recovered from COVID-19. This review article highlights the pandemic conditions in different parts of the world, as well as possible reasons behind minimal COVID-19 infections and the high mortality rates. It will discuss information about China’s strategies to cope with SARS-CoV-2 which can help other countries to mitigate viral spread and infection.
Aqueous extract of Azadirachta indica leaves favorably alters the course of streptozotocin-induced diabetes in rats: A comparative prospective cohort study
by Ezeigwe
O.,
Ezeonu
F.,
Okani
C.,
Onwusulu
D.,
Onuegbu
M.
Summary: Azadirachta indica (neem) is one of the plants commonly used in African traditional medicine for the treatment and management of diabetes mellitus. The present study was undertaken to evaluate the effect of aqueous extract of A. indica leaves on hematology, lipid profile and organ-system function of streptozotocin-induced diabetic male rats.
Comparative cytotoxic effects of methanol, ethanol and DMSO on human cancer cell lines
by Nguyen
S.,
Nguyen
H.,
Truong
K.
Summary: Anti-tumor drug screening is the most popular technique in drug discovery. In this technique, various agents were tested for their cytotoxicity on cell lines, particularly cancer cell lines. Since most of these agents are weakly soluble in water, they can be normally dissolved in lipophilic solvents. To obtain accurate results, the requirement of these solvents are that they be biocompatible and non-toxic to cells. The aim of this study was to investigate the biological effects of the three agents most commonly used as drug vehicles, i.e. dimethyl sulfoxide (DMSO), ethanol and methanol, using cell proliferation measurement techniques.
Dynamics of the microbiological scope and antibiotic susceptibility in intensive care unit patients
by Olga
K.,
Elena
Y.,
Sviatoslav
K.,
Dmytro
D.,
Kostiantyn
D.
Summary: This study addresses and evaluates the decrease of antibiotic resistance after introduction of a proposed prevention plan and control complex in the intensive care unit (ICU).
Antioxidant effects of hydro-alcoholic extract of Ashrasi date palm in hepatotoxicity caused by mercuric chloride administration
by Roshankhah
S.,
Shabanizadeh
A.,
Abdolmaleki
A.,
Salahshoor
M.
Summary: date palm (ADP) is a flowering plant type of the palm family which has strong antioxidant properties. Mercuric chloride (MC) is a complex substance that generates oxidative stress. This study was designed to investigate the protective effects of ADP on the , inflammatory, oxidative and apoptotic changes induced by MC.
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Phuc Van Pham, Editor-in-Chief
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Why publish with Biomedical Research and Therapy
ISSN: 2198-4093
DOI Prefix: 10.15419 (from Vol3, I11), 10.7603 (from Vol1, I1 to Vol3, I10)
Indexed: Web of Science (ESCI - Emerging Sources Citation Index, Clarivate Analytics)
Editor-in-Chief
Phuc Van Pham
University of Science, Vietnam National University, Ho Chi Minh city, Vietnam
Managing Editor
Lili Hami
University of Science, Vietnam National University, Ho Chi Minh city, Vietnam
Contact:
Editor-in-Chief: pvphuc@bmrat.org
Support Team: support@bmrat.org
Managing Editor: managingeditor@bmrat.org
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