journal description

Biomedical Research and Therapy - The Vietnamese Journal of Biomedicine fully open access journal of original research across a broad spectrum of medical scientific disciplines and sub-specialties. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. The peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.

Biomedical Research and Therapy's Editorial Policies follow the recommendations of the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE) for guidance on policies and procedures related to publication ethics. 

The journal is published monthly, 12 issues per year.


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Featured Articles

latest articles


Pathophysiology of diabetes mellitus complications: Metabolic events and control

by Ohiagu F., Chikezie P., Chikezie C.

Summary: Diabetes mellitus (DM) is a metabolic disorder that is characterized by hyperglycemia and glucose intolerance, which is associated with impaired insulin secretion and peripheral sensitivity and eventual b-cell dysfunction. This review summarized the major metabolic pathways leading to both microvascular and macrovascular complications in DM, with a view of highlighting the enzymes involved and the possible inhibition of the enzymes facilitating these processes as a measure of diabetic control.


Antigen-presenting cell-derived extracellular vesicles in accelerating atherosclerosis

by Berezin A., Berezin A.

Summary: Extracellular vesicles (EVs) are a population of heterogeneous particles that originate from the endosomal system or plasma membrane. Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. APC-derived EVs contain several bioactive molecules, such as non-coding RNAs, cytokines, chemokines, active proteins, immunomodulatory factors, and growth factors. The review focuses on the role of APC-derived EVs in regulating the transformation of macrophage phenotype, shaping foam cells, driving autophagy and/or inhibiting apoptosis of Th4+ cells, T regulatory cells, endothelial and smooth muscle cells (SMCs), as well as in facilitating oxidative stress in vasculature. APC-derived EVs act as triggers of angiogenesis, neovascularization and inflammation through their participation in microvascular inflammation, angiogenesis, development of atherosclerotic plaques, and modulation of their instability.

Research articles

Antioxidant and anti-Helicobacter pylori activities of Hericium erinaceus mycelium and culture filtrate

by Thi My Ngan L., Thien Vi N., Thi Mong Tham D., Thi Thanh Loan L., Thanh Ho P., Trung Hieu T.

Summary: Hericium erinaceus is known as a medicinal edible mushroom owing to its antimicrobial, antioxidant, anti-tumor and immunomodulatory effects. Helicobacter pylori infection is one of the major health concerns worldwide due to its high rate in global populations, frequent recurrence, and rapid emergence of drug-resistant strains. The present study aims to investigate antioxidant anti-H. pylori and urease inhibitory activities of solvent fractions from H. erinaceus mycelium and culture filtrate.

Research articles

Advantages of functional analysis in comparison of different chemometric techniques for selecting obesity-related genes of adipose tissue from high-fat diet-fed mice

by Dharmaraj S., Mahadeva R., Simbak N.

Summary: Obesity is a lifestyle disease that is becoming prevalent nowadays and is associated with a surplus in energy balance related to lipid metabolism, inflammation and hypoxic condition, resulting in maladaptive adipose tissue expansion. This study used the publicly available gene dataset to identify a small subset of important genes for diagnostics or as potential targets for therapeutics.

Research articles

Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology

by Martusevich A., Zagrekov V., Belyaeva K., Pushkin A., Soloveva A.

Summary: The purpose of this study was to evaluate and compare the features of the initiation and development of oxidative stress in patients with osteomyelitis and burns.

Research articles

The effect of regular aerobic activity on cortisol levels in female Wistar rats

by Ibrahimaj Gashi A., Azemi A., Zivkovic V., Gontarev S., Gjorgovski I.

Summary: Physical inactivity has been identified as a major risk factor for global mortality, causing approximately 2 million deaths globally, whereas the physical activity of moderate intensity has significant benefits for health. Exposure to stress results in changes in the endocrine and autonomic nervous systems, as well as behavioral changes which allow an organism to adapt to environmental changes. This study aimed to assess changes in cortisol levels and body temperature in rats after forced swim tests.

Research articles

The value of the Global Registry of Acute Coronary Events and Gensini scores in predicting long-term outcomes in Vietnamese patients with non-ST-elevation acute coronary syndrome

by Van Hoang S., Minh Nguyen K., Hoang Nguyen A., Le Anh Huynh K., Phuong Nguyen Tran H.

Summary: Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) should undergo risk stratification as soon as possible after their presentation. Early risk satisfaction provides good prognosis for patients as well as better decision for reperfusion therapy. The aim of this study is to find a correlation between the Global Registry of Acute Coronary Events (GRACE) risk score and severity of coronay artery disease assessed by Gensini score score and compare the value of GRACE and Gensini scores in predicting the long-term outcomes in patients with NSTE-ACS.


Evaluating the effectiveness of using enoxaparin to prevent venous thromboembolism in hip replacement patients: A retrospective cohort study

by Thanh Toan V., Dong Kha T., Van Anh B.

Summary: Our research aims to evaluate the effectiveness of thromboprophylaxis using enoxaparin in patients undergoing hip replacement.


Evaluation of renal cyst treatment using retroperitoneal laparoscopic decortication

by Ho U., Dam C., Le N.

Summary: Renal cyst is a common disease of the renal parenchyma. The management options include percutaneous aspiration with or without sclerotherapy, open surgery, and laparoscopic decortication of renal cyst. Laparoscopic renal cyst decortication is a safe and effective alternative with a high success rate. This study aimed to evaluate renal cyst treatment by retroperitoneal laparoscopic decortication.

Research articles

Effectiveness of elective single versus double frozen embryo transfer in good prognosis IVF patients

by Thanh T., Huy P., Linh D., Loc N., Duy N., Vinh D., Huyen N.

Summary: This study aimed to evaluate the effectiveness of elective single embryo transfer (eSET) versus double embryo transfer (DET) in frozen embryo transfer cycles following in vitro fertilization (IVF) treatment in good prognosis patients. The outcome would provide medical data for the multiple pregnancy rate reduction in IVF treatment.

Case report

Effect of drug-induced pathomorphosis on oral cavity organs and tissues in chronic obstructive pulmonary disease combined with coronary heart disease: A clinical case

by Emelyanova N., Komir I.

Summary: This article describes a clinical case of a patient, as well as literature data confirming the direct mutual influence of lesions in the oral cavity and the bronchocardiac complex pathology. Special attention is paid to the side effects of the main drugs prescribed in the basic therapy of chronic obstructive pulmonary disease, combined with coronary heart disease. It is noted that the drug-induced pathomorphosis can cause the development of periodontal lesions. Insufficient knowledge of these issues and the practical need for corrective measures to be taken by dentists with this category of patients warrant the relevance of research in this direction.


Concise review: The role of cancer-derived exosomes in tumorigenesis and immune cell modulation

by Thao Huynh N., Duy Pham K., Chau Truong N.

Summary: Exosomes are subcellular entities which were first discovered in the 1980s. Over the past decade, scientists have discovered that they carry components of genetic information that allow for cell-cell communication and cell targeting. Exosomes secreted by cancer cells are termed cancer-derived exosomes (CDEs), and play an important role in tumor formation and progression. Specifically, CDEs mediate the communication between cancer cells, as well as between cancer cells and other cells in the tumor microenvironment, including cancer-associated fibroblasts, endothelial cells, mesenchymal stem cells, and effector immune cells. Additionally, through the vascular system and body fluids, CDEs can modulate response to drugs, increase angiogenesis, stimulate proliferation, promote invasion and metastasis, and facilitate escape from immune surveillance. This review will discuss the relationship between cancer cells and other cells (particularly immune cells), as mediated through CDEs, as well as the subsequent impact on tumorigenesis and immunomodulation. Understanding the role of CDEs in tumorigenesis and immune cell modulation will help advance their utilization in the diagnosis, prognosis, and treatment of cancer.


Current strategies for adoptive immunotherapy for cancer: ”Off-the-shelf” immune cells

by Ngo Trong H., Le Van Manh H., Thanh Dang V., Ho-Thao Nguyen N., Vu Thanh B., Pham P.

Summary: Immunotherapy, especially immune cell-based therapy, is a strategy for cancer treatment that has over the past decades focused on novel modifications and targets. In recent years, adoptive cell immunotherapy has continuously evolved, with studies of different platforms utilizing different immune effector cells to kill a variety of cancer cells. This review summarizes the various kinds of immune cells which have been used in adoptive cell therapy (ACT), including natural killer cells, cytokine-induced killer cells, T cells, and engineered immune cells. Most reports have shown that ACT can induce tumor regression, both in animal studies and clinical trials. However, the high cost of ACT is the greatest disadvantage of this strategy. Moreover, the efficacy of treatment is variable among patients. To reduce these disadvantages, off-the-shelf immune cells are considered the best solution to reduce the cost while maintaining the efficacy of treatment. In this review, we will discuss the potential of various kinds of immune cells for development as ``off-the-shelf'' immune cells for use in adoptive cell therapy, based on their unique advantages.


A retrospective analysis of pyogenic liver abscess and antibiotic resistivity of common pathogens in Peshawar

by Bashir N., Adnan Shereen M., Kazmi A., Sajid M., Ullah H.

Summary: Pyogenic liver abscess (PLA) is a rare but life-threatening disease, with a frequency ranging from 10.83 to 17.45 per 100,000 persons. The major cause of PLA is bacterial infection of liver parenchyma. The present research study was designed to investigate the common microbes causing PLA in Peshawar (Pakistan) and to evaluate a variety of the most capable and efficient antibiotics for treatment of PLA.



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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

Why publish with Biomedical Research and Therapy




Aims & Scope of Biomedical Research and Therapy updated


Biomedical Research and Therapy (ISSN 2198-4093) was published by Springer in Global Science Journals from 2014-2015, and BioMedPress from 2016 to now. As a result of a revolution, and to improve the journal quality, the publisher decided to revise the aims and scope of Biomedical Research and Therapy.

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Copyright 2014-2018 BioMedPress. This work is licensed under a Creative Commons Attribution 4.0 License. A partner of HINARI, AGORA, OARE, Crossref