Publisher Home
Featured Articles
latest articles
Clinical data analysis of dengue fever severity identification
by Zainee
N.,
Chellappan
K.,
Vehi
J.,
Periyasamy
P.,
Man
Z.
Summary: The dynamic nature of dengue fever demands rapid and repeated clinical detection based on the vital signs variables, blood profile, and symptoms for providing timely clinical treatment. Patients with or without warning signs are at risk of contracting the severe dengue; thus, this study aims to identify the vital signs and blood profile variables that would differentiate the severity levels of dengue fever among dengue patients.
Disorders of proteolytic homeostasis in the liver of rats with hyperhomocysteinemia
by Nataliia
R.,
Yuliia
H.,
Yurii
G.,
Tetiana
V.,
Daryna
K.,
Tetiana
H.,
Olga
K.,
Olexiy
S.,
Lydmila
O.,
Oleksandr
M.
Summary: The liver is a key organ of the body that is responsible for maintaining homeostasis. It helps regulate almost all biochemical pathways associated with metabolism, nutrition, energy supply, and the formation of immunity. Consequently, impaired liver function can contribute to the progression of hyperhomocysteinemia and the development of associated complications. The present study aims to investigate the level and activity of metal-dependent and serine proteases in the liver of rats with hyperhomocysteinemia.
Transplantation of mesenchymal stem cell sheet to treat acute hind-limb ischemia: A preclinical study
by Le
T.,
Dang
G.,
Phat
H.,
Ngoc
V.
Summary: Mesenchymal stem cell (MSC) transplantation has been reported as a promising therapy for acute limb ischemia (ALI). However, the treatment efficacy is limited to only certain improvements. Therefore, this study aims to improve the treatment efficacy of MSC transplantation through the use of MSC sheets produced from MSCs' cultured in fibrin scaffold (Fi-MSCs) in ALI models.
Preclinical toxicological evaluation of measles virus vaccine strain in non-human primates: A two-month intravenous study
by Thanh Chung
D.,
Thi Long
H.,
Van Tong
H.,
Thu Hang
N.,
Thu Huong
N.,
Khac Cuong
B.,
Van Tran
P.,
Thuy Linh
N.,
Dang Hien
N.,
Van Mao
C.,
Duc Thuan
N.,
Linh Toan
N.,
Thanh Tung
N.,
Anh Son
H.
Summary: Based on its ability to kill tumor cells, the vaccine strain of the measles virus is used for oncolytic virotherapy. However, the dose required for cancer therapy is much higher than that used for vaccination. Therefore, this study was conducted to evaluate the preclinical toxicology of the vaccine strain of measles virus in monkeys.
Pachyonychia Congenita Type PC-K6a: The first report in the Vietnamese population
by Chu
H.,
Le
D.,
Le
T.,
Nguyen
B.,
Schwartz
J.,
Vu
Q.
Summary: Pachyonychia congenita (PC) comprises a group of rare autosomal dominant genetic disorders. It is characterized by hypertrophic nail dystrophy, focal palmoplantar keratoderma, follicular keratosis, and oral leukokeratosis. It is associated with mutations in five differentiationspecific keratin genes: KRT6A, KRT6B, KRT6C, KRT16, or KRT17. The case is being reported for its rarity. To the best of our knowledge, this is the first report of PC, from Vietnam, confirmed by genetic analysis.
Mechanisms in Tridax procumbens leaf extract reversal of paroxetine-induced erectile dysfunction in corpus cavernosum of male Wistar rats
by Salami
S.,
Salahdeen
H.,
Balogun
Z.,
Murtala
B.,
Raji
Y.
Summary: Aqueous leave extract of Tridax procumbens (AETPL) is reported to improve erectile functions; however, the mechanism is unclear. This study investigates the mechanism involved in the contractile activity of the corpus cavernosum after AETPL treatment of paroxetine-induced erectile dysfunctional adult male Wistar rats.
Neutrophils’ functional activity in patients with mechanical jaundice and different levels of bilirubin
by Darenskaya
M.,
Kolesnikova
L.,
Smirnova
O.,
Gubanov
B.,
Kasparov
E.,
Kolesnikov
S.
Summary: Mechanical jaundice (MJ) or bile duct blockage occurs when the bile ducts' patency is impaired, and the bile flow has stopped. One of the main pathogenetic factors developing complications with MJ is immune system imbalance, particularly its phagocytic link. The purpose of the study was to understand neutrophils' functional activity dependence with different blood bilirubin levels in men with mechanical jaundice.
Conditioned media from human adipose-derived stem cell culture in some stressed culture conditions differ angiogenic potential
by Vu
N.,
Vu
B.,
Nguyen
K.,
Pham
P.
Summary: The potency of mesenchymal stem cells (MSCs) related to their biological effects includes immune modulation and angiogenesis. Recently, some stress conditions were applied to enhance the angiogenic potential of MSCs. This study aimed to assess the effects of conditioned media (CM) collected from adipose-derived stem cells’ (ADSCs’) culture under various stress conditions on angiogenesis in vitro.
Vitamin D and COVID-19: A Physiological Perspective
by Sindhusen
P.
Summary: Known for its ability to enhance the performance of the immune system, preclude microbial infections, and reduce susceptibility to influenza, Vitamin D (or 1,25-dihydroxyvitamin D (1,25(OH)2D) as the active form) has garnered a positive reputation in the management of COVID-19 for some time. Its deficiency is statistically correlated with infection of the disease, as well as disease severity and fatalities. There have been suggestions that Vitamin D supplements could either prevent the contraction of SARS-CoV-2, the coronavirus which causes the disease or alleviate the symptoms of the disease. Indeed, data have established a relationship between Vitamin D supplementation and the severity of respiratory illnesses, with some assays indicating optimistic results in COVID-19 patients who were supplemented with the vitamin. Accordingly, a great deal of research and efforts have been put into investigating the physiological mechanisms in the human body attributable to the vitamin’s reputation against the coronavirus. Combined with what was already discovered before the advent of SARS-CoV-2, a great amount of knowledge has consequently now been unveiled. Via regulation of various pathways, 1,25(OH)2D promotes the production of antimicrobial peptides, autophagy, as well as integrity and impermeability of cellular junctions against pathogens. Moreover, it mitigates the consequences of SARS-CoV-2 infection, such as cytokine storm (through immunomodulation of T cell differentiation pathways) and lung injury (through stimulation of the Angiotensin-Converting Enzyme 2 (ACE2) and manipulation of the Renin-Angiotensin System (RAS)). Nevertheless, Vitamin D deficiency still plagues the global population across all age groups, possibly contributing to the heightened global exposure to the coronavirus. With the COVID-19 pandemic inexorably raging on with no prospect of termination observable in the foreseeable future, this review article provides a concise yet thorough insight into the vast knowledge which could illuminate the significance of Vitamin D amidst the current predicament experienced by mankind, as well as instigate further curiosity and ignite further investigations into the role of vitamins, such as Vitamin D, as a safeguard against SARS-CoV-2.
Immunological and mutational analysis of SARS-CoV-2 structural proteins from Asian countries
by Jha
D.,
Yashvardhini
N.,
Kumar
A.
Summary: The emergence of a novel coronavirus, SARS-CoV-2, an etiologic agent of coronavirus disease (COVID-19), has led to a pandemic of global concern. Considering the huge number of morbidity and mortality worldwide, the World Health Organization declared, on 11th March 2020, the pandemic as an unprecedented public health crisis. The virus is a member of plus sense RNA viruses that can show a high rate of mutations. The ongoing multiple mutations in the structural proteins of coronavirus drive viral evolution, enabling them to evade the host immunity and rapidly acquire drug resistance. In the present study, we focused mainly on the prevalence of mutations in the four types of structural proteins- S (spike), E (envelope), M (membrane), and N (nucleocapsid)- that are required for the assembly of a complete virion particle. Further, we estimated the antigenicity and allergenicity of these structural proteins to design and develop a potentially good candidate vaccine against SARS-CoV-2.
Effect of rose extract treatment on soluble CCR5 and CXCR4 secretion by the endothelial cells in vitro
by Arokiaraj
M.,
Menesson
E.
Summary: CC-Chemokine Receptor 5 (CCR5) and Chemokine C-X-C-Motif Receptor 4 (CXCR4) are expressed in various tissues, and they are potential molecules involved in multiple pathways. CCR5 and CXCR4 targets are associated with immune regulation in patients in multiple tissues and numerous clinical conditions. The study was performed searching for a novel therapy for immune regulation on these CCR5 and CXCR4 receptors with rose extract.
Morphokinetic parameters comparison between euploid and aneuploid blastocysts
by Le
P.,
Le
A.,
Nguyen
L.,
Dang
V.
Summary: Pre-implantation genetic testing for aneuploidy (PGT-A) has been using for years in embryoselection. However, this is an invasive method and may cause harm to the embryos. Therefore, time-lapse monitoring has been thought to be an alternative approach for embryo selection due to its efficiency. Up to now, several studies were investigating the relationship between the morphokinetic parameters and the embryo ploidy. However, the results are not consistent. This study aims to evaluate the correlation between morphokinetic parameters and PGT-A results.
Characterization of white matter branching in human cerebella: quantitative morphological assessment and fractal analysis of skeletonized MR images
by Maryenko
N.,
Stepanenko
O.
Summary: The aim of the present study was to investigate branching characteristics of the human cerebellar white matter by the means of findings obtained from the quantitative morphological assessment and fractal analysis of the skeletonized MR images of the human cerebellum.
In vivo study of wound healing processes in Sprague-Dawley model using human mesenchymal stem cells and platelet-rich plasma
by Karina
K.,
Biben
J.,
Ekaputri
K.,
Rosadi
I.,
Rosliana
I.,
Afini
I.,
Widyastuti
T.,
Sobariah
S.,
Subroto
W.
Summary: Mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) have a potential role in improving wound healing processes. This experimental study aims to compare PRP and MSCs to promote the wound healing process in the animal burn wound model.
Upcoming events
Innovations in Cancer Research and Regenerative Medicine
Journal Supplements
Conference Abstracts
Journal Collections
Stem Cells and Regenerative Medicine
Special Issues
Special Issues
Journal Collections
Natural Extract
Publication Awards
The best original research articles
Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
ISSN: 2198-4093
DOI Prefix: 10.15419 (from Vol3, I11), 10.7603 (from Vol1, I1 to Vol3, I10)
Indexed: Web of Science (ESCI - Emerging Sources Citation Index, Clarivate Analytics)
Editor-in-Chief
Phuc Van Pham
University of Science, Vietnam National University, Ho Chi Minh city, Vietnam
Managing Editor
Lili Hami
University of Science, Vietnam National University, Ho Chi Minh city, Vietnam
Contact:
Editor-in-Chief: pvphuc@bmrat.org
Support Team: support@bmrat.org
Managing Editor: managingeditor@bmrat.org
Advertisement
Follow us
